Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Skepinone-L

Skepinone-L

Skepinone-L Structure
Skepinone-L structure
CAS No.
1221485-83-1
Chemical Name:
Skepinone-L
Synonyms
CS-1010;CBS3830;SKEPINONE;Skepinone-L;Skepinone-L, >=98%;Skepinone-L (CBS3830);Skepinone-L USP/EP/BP;inhibit,SkepinoneL,Skepinone-L,CBS-3830,Skepinone L,CBS 3830,Autophagy,p38 MAPK,Inhibitor;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann;3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
CBNumber:
CB52628399
Molecular Formula:
C24H21F2NO4
Molecular Weight:
425.42
MDL Number:
MFCD22572738
MOL File:
1221485-83-1.mol
MSDS File:
SDS
Last updated:2024-11-06 15:28:16
Request For Quotation

Skepinone-L Properties

Melting point 130-134°C
Boiling point 629.0±55.0 °C(Predicted)
Density 1.384±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility DMSO (Slightly), Methanol (Slightly)
pka 13.49±0.20(Predicted)
form Solid
color Light Yellow to Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2922500090
NFPA 704
0
2 0

Skepinone-L price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16974 Skepinone-L ≥98% 1221485-83-1 500μg $49 2024-03-01 Buy
Cayman Chemical 16974 Skepinone-L ≥98% 1221485-83-1 1mg $92 2024-03-01 Buy
Cayman Chemical 16974 Skepinone-L ≥98% 1221485-83-1 5mg $380 2024-03-01 Buy
Cayman Chemical 16974 Skepinone-L ≥98% 1221485-83-1 10mg $665 2024-03-01 Buy
TRC S499000 Skepinone-L 1221485-83-1 25mg $945 2021-12-16 Buy
Product number Packaging Price Buy
16974 500μg $49 Buy
16974 1mg $92 Buy
16974 5mg $380 Buy
16974 10mg $665 Buy
S499000 25mg $945 Buy

Skepinone-L Chemical Properties,Uses,Production

Description

Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation.

Uses

Skepinone-L is a potent and highly selective inhibitor of p38 MAP kinase which impairs platelet activation and thrombus formation.

target

p38-MAPK

References

[1]. koeberle, s c et al., skepinone-l is a selective p38 mitogen-activated protein kinase inhibitor. nature chemical biology, 2012, 8(2), 141-143.

Skepinone-L Preparation Products And Raw materials

Raw materials

Preparation Products

Skepinone-L Suppliers

Global( 79)Suppliers
Supplier Tel Email Country ProdList Advantage
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32063 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 23125 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38463 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Supplier Advantage
Biochempartner 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58

View Lastest Price from Skepinone-L manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Skepinone-L pictures 2024-11-06 Skepinone-L
1221485-83-1
 US $32.00-72.00 / mg 99.76% 10g TargetMol Chemicals Inc.
  • Skepinone-L pictures
  • Skepinone-L
    1221485-83-1
  • US $32.00-72.00 / mg
  • 99.76%
  • TargetMol Chemicals Inc.

Skepinone-L Spectrum

Skepinone-L(1221485-83-1)1HNMR

1221485-83-1(Skepinone-L)Related Search:

Sivelestat sodium Sitaxentan sodium Sitravatinib MK-2206 2HCl 1,9-Pyrazoloanthrone
Saracatinib TAK-632 PP2 Fedratinib

1of2

5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro- Skepinone-L, >=98% 3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one (R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann Skepinone-L 2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one CS-1010 SKEPINONE CBS3830 Skepinone-L USP/EP/BP Skepinone-L (CBS3830) (R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one inhibit,SkepinoneL,Skepinone-L,CBS-3830,Skepinone L,CBS 3830,Autophagy,p38 MAPK,Inhibitor 1221485-83-1 C24H21F2NO4 MAPK Inhibitors