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2-Amino-4-bromo-3-fluorobenzoic acid

2-Amino-4-bromo-3-fluorobenzoic acid structure

CAS No.: 1416013-62-1

Chemical Name:: 2-Amino-4-bromo-3-fluorobenzoic acid

Synonyms: 140622;Ethanol,5-diazenyl-;Oxymetazoline Impurity 10;3-BROMO-6-CARBOXY-2-FLUOROANILINE;2-amino-4-bromo-3-fluorobenzoicaci;2-Amino-3-fluoro-4-bromobenzoic acid;2-Amino-4-bromo-3-fluorobenzoic acid;Benzoic acid, 2-amino-4-bromo-3-fluoro-

CBNumber:: CB52697454

Molecular Formula:: C7H5BrFNO2

Molecular Weight:: 234.02

MDL Number:: MFCD27664889

MOL File:: 1416013-62-1.mol

MSDS File:: SDS

Last updated:2024-12-12 13:55:44

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2-Amino-4-bromo-3-fluorobenzoic acid Properties

Boiling point	332.0±42.0 °C(Predicted)
Density	1.877±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	4.37±0.10(Predicted)
form	powder
color	Off white
InChI	InChI=1S/C7H5BrFNO2/c8-4-2-1-3(7(11)12)6(10)5(4)9/h1-2H,10H2,(H,11,12)
InChIKey	SFRJQFICUQFDFU-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC=C(Br)C(F)=C1N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P271-P261-P280
HS Code	2922498590

2-Amino-4-bromo-3-fluorobenzoic acid price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A577113	2-Amino-4-Bromo-3-FluorobenzoicAcid	1416013-62-1	1g	$45	2021-12-16	Buy
Apolloscientific	PC500189	2-Amino-4-bromo-3-fluorobenzoicacid 95%	1416013-62-1	1g	$67	2021-12-16	Buy
SynQuest Laboratories	4657-B-00	2-Amino-4-bromo-3-fluorobenzoic acid	1416013-62-1	250mg	$72	2021-12-16	Buy
AK Scientific	Y1761	2-Amino-4-bromo-3-fluorobenzoicacid	1416013-62-1	100mg	$80	2021-12-16	Buy
Apolloscientific	PC500189	2-Amino-4-bromo-3-fluorobenzoicacid 95%	1416013-62-1	250mg	$37	2021-12-16	Buy

Product number	Packaging	Price	Buy
A577113	1g	$45	Buy
PC500189	1g	$67	Buy
4657-B-00	250mg	$72	Buy
Y1761	100mg	$80	Buy
PC500189	250mg	$37	Buy

2-Amino-4-bromo-3-fluorobenzoic acid Chemical Properties,Uses,Production

Description

2-Amino-4-bromo-3-fluorobenzoic acid is an important pharmaceutical and organic intermediate ingredient used in the synthesis of avibactam sodium, an FDA-approved non-beta-lactam β-lactamase inhibitor used in combination with ceftazidime (Avycaz). It is used for the treatment of complicated intra-abdominal infections, urinary tract infections, and pyelonephritis.

Uses

2-Amino-4-Bromo-3-Fluorobenzoic Acid is used in preparation of Quinazoline compounds as KRAS modulators and antitumor agents.

Synthesis

The synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid is as follows:
To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 oC, H2O2 (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na2SO3, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield).
synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid.png

2-Amino-4-bromo-3-fluorobenzoic acid synthesis

Synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid from 6-bromo-7-fluoroisatin

2-Amino-4-bromo-3-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

6-bromo-7-fluoroisatin 4-BROMO-2,3-DIFLUOROBENZOIC ACID

Preparation Products

2-Amino-4-bromo-3-fluorobenzoic acid Suppliers

Global( 169)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14427	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Changsha YuTeng New Materials Co., Ltd.	+86-13487087296 +86-13787794286	rainbowz@cs-yuteng.com	China	37	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Zjartschem	+86-571 87238903	jocelynpan@zjarts.com	CHINA	988	58
Win-Win Chemical CO., Limited	0086-577-64498589	sales@win-winchemical.com	CHINA	998	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10311	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2958	58

Supplier	Advantage
Win-Win chemical CO., Limited	58
Amadis Chemical Company Limited	58
Changsha YuTeng New Materials Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Zjartschem	58
Win-Win Chemical CO., Limited	58
Changzhou Ansciep Chemical Co., Ltd.	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from 2-Amino-4-bromo-3-fluorobenzoic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-12-25	2-Amino-4-bromo-3-fluorobenzoic acid 1416013-62-1	US $0.00-0.00 / g	100g	98%	500kg/M	Changsha YuTeng New Materials Co., Ltd.
	2020-01-01	2-Amino-4-bromo-3-fluorobenzoic acid 1416013-62-1	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

2-Amino-4-bromo-3-fluorobenzoic acid
1416013-62-1
US $0.00-0.00 / g
98%
Changsha YuTeng New Materials Co., Ltd.

2-Amino-4-bromo-3-fluorobenzoic acid
1416013-62-1
US $1.00 / KG
99%
Career Henan Chemical Co

2-Amino-4-bromo-3-fluorobenzoic acid Spectrum

2-Amino-4-bromo-3-fluorobenzoic acid(1416013-62-1)¹HNMR

1416013-62-1(2-Amino-4-bromo-3-fluorobenzoic acid)Related Search:

no 2-Amino-6-bromopyridine 2-Amino-4-bromopyridine 3-METHOXY-2-AMINOBENZAMIDE 2-Amino-5-bromopyrazine

2-Amino-4-bromo-3-fluorobenzoic acid 3-BROMO-6-CARBOXY-2-FLUOROANILINE 140622 Benzoic acid, 2-amino-4-bromo-3-fluoro- Ethanol,5-diazenyl- 2-amino-4-bromo-3-fluorobenzoicaci 2-Amino-3-fluoro-4-bromobenzoic acid Oxymetazoline Impurity 10 1416013-62-1