NBQX DISODIUM SALT
- CAS No.
- 118876-58-7
- Chemical Name:
- NBQX DISODIUM SALT
- Synonyms
- NBQX;FG 9202;NBQX NEW;NBQX HYDRATE;NBQX DISODIUM;FG 9202 DISODIUM;Dihydroxyquinone;NBQX DISODIUM SALT;FG9202;FG-9202;FG 9202;NBQX disodium salt hydrate
- CBNumber:
- CB5274224
- Molecular Formula:
- C12H8N4O6S
- Molecular Weight:
- 336.28
- MDL Number:
- MFCD00274065
- MOL File:
- 118876-58-7.mol
- MSDS File:
- SDS
Melting point | 361°C |
---|---|
Density | 1.6027 (rough estimate) |
refractive index | 1.6000 (estimate) |
storage temp. | Inert atmosphere,2-8°C |
solubility | methanol: 0.25 mg/mL |
form | solid |
pka | 7.55±0.20(Predicted) |
color | yellow |
Stability | Freezer at -20°C |
InChIKey | UQNAFPHGVPVTAL-UHFFFAOYSA-N |
FDA UNII | 8LZ6Q43V2S |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
NBQX DISODIUM SALT price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | N171 | NBQX hydrate powder, ≥98% (HPLC) | 118876-58-7 | 5mg | $270 | 2024-03-01 | Buy |
Sigma-Aldrich | N171 | NBQX hydrate powder, ≥98% (HPLC) | 118876-58-7 | 25mg | $444 | 2024-03-01 | Buy |
Sigma-Aldrich | N183 | NBQX disodium salt hydrate ≥98% (HPLC), lyophilized solid | 118876-58-7 | 5mg | $320 | 2024-03-01 | Buy |
Sigma-Aldrich | N183 | NBQX disodium salt hydrate ≥98% (HPLC), lyophilized solid | 118876-58-7 | 25mg | $1290 | 2024-03-01 | Buy |
Tocris | 0373 | NBQX ≥98%(HPLC) | 118876-58-7 | 50 | $910 | 2021-12-16 | Buy |
NBQX DISODIUM SALT Chemical Properties,Uses,Production
Chemical Properties
Yellow Crystalline Solid
Uses
A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.
Uses
NBQX disodium salt hydrate has been used:
- in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
- as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
- in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSCNMDAR)
Definition
ChEBI: 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline is a member of naphthalenes and a sulfonic acid derivative.
General Description
NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor.
Biological Activity
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo . More water soluble disodium salt of NBQX (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide ). Also available as part of the AMPA Receptor Tocriset™ .
Biochem/physiol Actions
NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear.
storage
Room temperature
NBQX DISODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Chemia Biotechnology(Shanghai) Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2972 | 58 |
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