XILVEPYQJIOVNB-ZEJCXXMWSA-N
- CAS No.
- 1329837-73-1
- Chemical Name:
- XILVEPYQJIOVNB-ZEJCXXMWSA-N
- Synonyms
- XILVEPYQJIOVNB-ZEJCXXMWSA-N
- CBNumber:
- CB53395711
- Molecular Formula:
- C18H14D4F3NO4
- Molecular Weight:
- 373.359676712
- MDL Number:
- MFCD34567904
- MOL File:
- 1329837-73-1.mol
XILVEPYQJIOVNB-ZEJCXXMWSA-N price More Price(2)
XILVEPYQJIOVNB-ZEJCXXMWSA-N Chemical Properties,Uses,Production
Uses
Medication used to alleviate joint and muscle pain.
Biological Activity
Etofenamate-d4 is intended for use as an internal standard for the quantification of etofenamate by GC- or LC-MS. Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid that has anti-inflammatory and analgesic activities.1,2 It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 in stimulated rat peritoneal macrophages.2 In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.1 Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.
References
1.Nakamura, H., Motoyoshi, S., Imazu, C., et al.Anti-inflammatory, analgesic and anti-pyretic activities of a non-steroidal anti-inflammatory drug, etofenamate, in experimental animalsNihon Yakurigaku Zasshi.80(2)125-135(1982) 2.Nakamura, H., Motoyoshi, S., Ishii, K., et al.The mode of anti-inflammatory action of a topical non-steroidal anti-inflammatory drug, etofenamateNihon Yakurigaku Zasshi.89(1)15-24(1987)
XILVEPYQJIOVNB-ZEJCXXMWSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
XILVEPYQJIOVNB-ZEJCXXMWSA-N Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7984 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd | 18162595016 | 3287908757@qq.com | China | 8852 | 58 |