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4-Aminohippuric acid

4-Aminohippuric acid Structure
4-Aminohippuric acid structure
CAS No.
61-78-9
Chemical Name:
4-Aminohippuric acid
Synonyms
PAH;P-AMINOHIPPURIC ACID;POLYNUCLEAR AROMATIC HYDROCARBONS;paha;Nefrotest;N-glycine;Aminohippuric;pah(aminoacid);AKOS BBS-00006940;p-amino-hippuricaci
CBNumber:
CB5348161
Molecular Formula:
C9H10N2O3
Molecular Weight:
194.19
MDL Number:
MFCD00007890
MOL File:
61-78-9.mol
MSDS File:
SDS
Last updated:2024-12-18 14:08:52
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4-Aminohippuric acid Properties

Melting point 199-200 °C (dec.)(lit.)
Boiling point 330.62°C (rough estimate)
Density 1.356
refractive index 1.5600 (estimate)
storage temp. Store below +30°C.
solubility DMF: 33 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 20 mg/ml
pka pKa 3.8 (Uncertain)
form Crystalline Powder
color Off-white to grayish
PH 3.0-3.5 (20g/l, H2O, 20℃)
Water Solubility Soluble in alcohol, chloroform, benzene, and acetone. Insoluble in water, ether, carbon, and tetrachloride.
Merck 14,442
BRN 1213676
InChIKey HSMNQINEKMPTIC-UHFFFAOYSA-N
CAS DataBase Reference 61-78-9(CAS DataBase Reference)
NCI Dictionary of Cancer Terms PAH
FDA UNII Y79XT83BJ9
EPA Substance Registry System P-Aminohippuric acid (61-78-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  37/39-26-36
WGK Germany  3
F  8-9-23
TSCA  Yes
HS Code  29242990
Hazardous Substances Data 61-78-9(Hazardous Substances Data)
NFPA 704
1
0 1

4-Aminohippuric acid price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR3174 Aminohippuric Acid pharmaceutical secondary standard, certified reference material 61-78-9 500MG $200 2024-03-01 Buy
Sigma-Aldrich 8.14621 4-Aminohippuric acid for synthesis 61-78-9 25g $191 2024-03-01 Buy
Sigma-Aldrich 08090 p-Aminohippuric acid ≥98.0% (T) 61-78-9 50g $387 2023-01-07 Buy
TCI Chemical A0313 4-Aminohippuric Acid >99.0%(T) 61-78-9 10g $171 2024-03-01 Buy
TCI Chemical A0313 4-Aminohippuric Acid >99.0%(T) 61-78-9 25g $342 2024-03-01 Buy
Product number Packaging Price Buy
PHR3174 500MG $200 Buy
8.14621 25g $191 Buy
08090 50g $387 Buy
A0313 10g $171 Buy
A0313 25g $342 Buy

4-Aminohippuric acid Chemical Properties,Uses,Production

Description

4-Aminohippuric acid is a substrate for various renal transporters that has been used in the study of anion uptake in the kidney. It is a substrate for organic anion transporter 1 (OAT1; Km = 14.3 μM in X. laevis oocytes), the human inorganic phosphate transporter (NPT1; Km = 2.66 mM in HEK293 cells), and apical multidrug resistance protein (MDR2; Km = 880 μM in HEK293 cells). 4-Aminohippuric acid is a glycine amide form of 4-aminobenzoic acid . Formulations containing 4-aminohippuric acid have been used as markers to determine renal plasma flow.

Chemical Properties

off-white to greyish crystalline powder

Uses

p-Aminohippuric acid has been used as infusions to measure plasma flow.

Uses

muscle relaxant (smooth)

Uses

4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.

Definition

ChEBI: P-aminohippuric acid is an N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow. It has a role as a Daphnia magna metabolite. It is a conjugate acid of a p-aminohippurate.

General Description

Renal tubules secretes para amino hippuric acid/PAH.

Biochem/physiol Actions

Para-aminohippuric acid(PAH) is used as a marker in nutrition studies to measure the flow of blood in pigs, which inturn helps to determine the portal-drained viscera (PDV) flux of nutrients.

Synthesis

4-Aminohippuric acid is prepared by reacting p-nitrobenzoyl chloride with glycine, followed by reducing the p-nitro group with tin and hydrochloric acid.

Purification Methods

Crystallise the acid from H2O. It is soluble in organic solvents. [Cohen & McGilvery J Biol Chem 169 119 1945, 171 121 1947, Meunzen et al. J Biol Chem 26 469 1926, Beilstein 14 III 1069, 14 IV 1152.]

References

[1] B. ZMBOVA . Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m[J]. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1989, 40 3: Pages 225-234. DOI:10.1016/0883-2889(89)90152-4.
[2] W P DEISS P P C. Studies in para-aminohippuric acid synthesis in the human: its application as a liver function test.[J]. Journal of Clinical Investigation, 1950, 29 8: 1014-1020. DOI:10.1172/JCI102332.
[3] M. SHEAT M. M Zenab F Saeed. Synthesis of Some of Azo, Triazines and Schiff Bases Compounds from 4-Aminohippuric Acid[J]. Journal of Education Science, 2009, 47 1: 1-8. DOI:10.33899/edusj.2009.57930.
[4] T SEKINE. Expression cloning and characterization of a novel multispecific organic anion transporter.[J]. The Journal of Biological Chemistry, 1997, 272 30: 18526-18529. DOI:10.1074/jbc.272.30.18526.
[5] HIROSHI UCHINO . p-Aminohippuric Acid Transport at Renal Apical Membrane Mediated by Human Inorganic Phosphate Transporter NPT1[J]. Biochemical and biophysical research communications, 2000, 270 1: Pages 254-259. DOI:10.1006/bbrc.2000.2407.

4-Aminohippuric acid Preparation Products And Raw materials

Raw materials

4-Nitrobenzoyl chloride Glycine Tin Hydrochloric acid

Preparation Products

4-Aminohippuric acid Suppliers

Global( 265)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Gubang New Materail Technology Co. LTD
21-51317962 +8618721305404 16728589@qq.com CHINA 272 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20282 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29793 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18750 58
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 8980 55
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Supplier Advantage
Shanghai Gubang New Materail Technology Co. LTD
58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hangzhou FandaChem Co.,Ltd. 		55
Hubei Jusheng Technology Co.,Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58

Related articles

View Lastest Price from 4-Aminohippuric acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Aminohippuric Acid pictures 2024-11-19 4-Aminohippuric Acid
61-78-9
 US $35.00-47.00 / mg 98.23% 10g TargetMol Chemicals Inc.
4-Aminohippuric Acid pictures 2024-11-19 4-Aminohippuric Acid
61-78-9
 US $35.00-47.00 / mg 98.23% 10g TargetMol Chemicals Inc.
4-Aminohippuric acid pictures 2024-04-25 4-Aminohippuric acid
61-78-9
 US $8.00-2.00 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

4-Aminohippuric acid Spectrum

4-AMINOHIPPURIC ACID(61-78-9)MS4-AMINOHIPPURIC ACID(61-78-9)1HNMR4-AMINOHIPPURIC ACID(61-78-9)13CNMR4-AMINOHIPPURIC ACID(61-78-9)IR14-AMINOHIPPURIC ACID(61-78-9)IR24-AMINOHIPPURIC ACID(61-78-9)Raman

61-78-9(4-Aminohippuric acid)Related Search:

L-Tetrahydrofolic Acid Folic acid Aminopterin P-NITROBENZOYL-L-GLUTAMIC ACID 4-Aminohippuric acid
P-AMINOHIPPURIC ACID SODIUM SALT N-(p-Aminobenzoyl)glutamic acid METHOTREXATE HYDRATE 5-METHYLTETRAHYDROFOLIC ACID DISODIUM SALT diethyl N-[4-(methylamino)benzoyl]-L-glutamate
DIHYDROFOLIC ACID N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID DIETHYL ESTER 4-NITROHIPPURIC ACID Calcium folinate (+/-)AMETHOPTERIN
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|p|-AMinohippuric acid (PAH) 2-[(4-aminophenyl)carbonylamino]ethanoic acid 2-[[(4-aminophenyl)-oxomethyl]amino]acetic acid Aminohippuric acid [USAN] Hippuric acid, p-amino- Hippuric acid, p-amino- (8CI) Nefrotest N-[(4-aminophenyl)carbonyl]glycine p-Aminohippuric acid (PAH) 4-Aminohippuric acid(p-Aminohippuric acid) n-(4-aminobenzoyl)-glycin n-(para-aminobenzoyl)glycine pah(aminoacid) 4-Aminohippuric acid;PAH P-AMINOHIPPURIC ACID FREE ACID 4-Aminohippuricacid,97% Aminohippuric Glycine, N-(4-aminobenzoyl)- 2-[(4-aminobenzoyl)amino]acetic acid N-(4-AMINOBENZOYL)GLYCINE / 4-AMINOHIPPURIC ACID 4-AMINOHIPPURIC ACID BIOTECH 4-Aminohippuric acid, N-(4-Aminobenzoyl)glycine, p-Aminohippuric acid 4-Aminohippuric acid,99% N-glycine 4-AMINOHIPPURIC ACID FOR SYNTHESIS 2-(4-AMinobenzaMido)acetic acid Aminohippuric Acid (200 mg) paha p-amino-hippuricaci para-aminohippuricacid AKOS BBS-00006940 (4-AMINO-BENZOYLAMINO)-ACETIC ACID 4-AMINOBENZOYL GLYCINE 4-AMINOHIPPURIC ACID 2-[4-AMINOPHENYLCARBOXYAMINO]-ACETIC ACID LABOTEST-BB LT00053657 MIXTURE NO 6-POLYNUCLEAR AROMATIC HYDROCARBONS N-4-AMINOHIPPURIC ACID N-(4-AMINOBENZOYL)AMINOACETIC ACID N-(4-AMINOBENZOYL)GLYCINE N-(P-AMINOBENZOYL)-AMINOACETIC ACID N-[P-AMINOBENZOYL]GLYCINE P-AMINOBENZOYLGLYCINE TIMTEC-BB SBB000329 4-Aminohippuric Acid > 4-AMINOHIPPURIC ACID USP/EP/BP Aminohippuric Acid (1025351) POLYNUCLEAR AROMATIC HYDROCARBONS PAH P-AMINOHIPPURIC ACID 4-Aminohippuric Acid, ≥ 99.0% 61-78-9 H2NC6H4CONHCH2COOH H2NC6D4CONHCH2COOH NH2C6H4CONHCH2COOH AMINE Peptide Synthesis Modified Amino Acids