4-Aminohippuric acid
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4-Aminohippuric acid 속성
- 녹는점
- 199-200 °C (dec.)(lit.)
- 끓는 점
- 330.62°C (rough estimate)
- 밀도
- 1.356
- 굴절률
- 1.5600 (estimate)
- 저장 조건
- Store below +30°C.
- 용해도
- DMF: 33 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 20 mg/ml
- 산도 계수 (pKa)
- pKa 3.8 (Uncertain)
- 물리적 상태
- 결정성 분말
- 색상
- 회백색에서 회색을 띤다
- 수소이온지수(pH)
- 3.0-3.5 (20g/l, H2O, 20℃)
- 수용성
- 알코올, 에 용해됨클로로포름, 벤젠, 아세톤에 용해됩니다. 물, 에테르, 탄소 및 사염화물에 용해되지 않습니다.
- Merck
- 14,442
- BRN
- 1213676
- InChIKey
- HSMNQINEKMPTIC-UHFFFAOYSA-N
- CAS 데이터베이스
- 61-78-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-20/21/22 | ||
안전지침서 | 37/39-26-36 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 8-9-23 | ||
TSCA | Yes | ||
HS 번호 | 29242990 | ||
유해 물질 데이터 | 61-78-9(Hazardous Substances Data) |
4-Aminohippuric acid C화학적 특성, 용도, 생산
개요
4-Aminohippuric acid is a substrate for various renal transporters that has been used in the study of anion uptake in the kidney. It is a substrate for organic anion transporter 1 (OAT1; Km = 14.3 μM in X. laevis oocytes), the human inorganic phosphate transporter (NPT1; Km = 2.66 mM in HEK293 cells), and apical multidrug resistance protein (MDR2; Km = 880 μM in HEK293 cells). 4-Aminohippuric acid is a glycine amide form of 4-aminobenzoic acid . Formulations containing 4-aminohippuric acid have been used as markers to determine renal plasma flow.화학적 성질
off-white to greyish crystalline powder용도
4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.정의
ChEBI: P-aminohippuric acid is an N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow. It has a role as a Daphnia magna metabolite. It is a conjugate acid of a p-aminohippurate.일반 설명
Renal tubules secretes para amino hippuric acid/PAH.Biochem/physiol Actions
Para-aminohippuric acid(PAH) is used as a marker in nutrition studies to measure the flow of blood in pigs, which inturn helps to determine the portal-drained viscera (PDV) flux of nutrients.Synthesis
4-Aminohippuric acid is prepared by reacting p-nitrobenzoyl chloride with glycine, followed by reducing the p-nitro group with tin and hydrochloric acid.Purification Methods
Crystallise the acid from H2O. It is soluble in organic solvents. [Cohen & McGilvery J Biol Chem 169 119 1945, 171 121 1947, Meunzen et al. J Biol Chem 26 469 1926, Beilstein 14 III 1069, 14 IV 1152.]참고 문헌
[1] B. ZMBOVA . Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m[J]. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1989, 40 3: Pages 225-234. DOI:10.1016/0883-2889(89)90152-4.[2] W P DEISS P P C. Studies in para-aminohippuric acid synthesis in the human: its application as a liver function test.[J]. Journal of Clinical Investigation, 1950, 29 8: 1014-1020. DOI:10.1172/JCI102332.
[3] M. SHEAT M. M Zenab F Saeed. Synthesis of Some of Azo, Triazines and Schiff Bases Compounds from 4-Aminohippuric Acid[J]. Journal of Education Science, 2009, 47 1: 1-8. DOI:10.33899/edusj.2009.57930.
[4] T SEKINE. Expression cloning and characterization of a novel multispecific organic anion transporter.[J]. The Journal of Biological Chemistry, 1997, 272 30: 18526-18529. DOI:10.1074/jbc.272.30.18526.
[5] HIROSHI UCHINO . p-Aminohippuric Acid Transport at Renal Apical Membrane Mediated by Human Inorganic Phosphate Transporter NPT1[J]. Biochemical and biophysical research communications, 2000, 270 1: Pages 254-259. DOI:10.1006/bbrc.2000.2407.
4-Aminohippuric acid 준비 용품 및 원자재
원자재
준비 용품
4-Aminohippuric acid 공급 업체
글로벌( 258)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 |
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Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
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Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
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Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9276 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29821 | 58 |
4-Aminohippuric acid 관련 검색:
요산 히푸르산 엽산 아미노프테린 폴린 산, 칼슘 염
L-Tetrahydrofolic Acid
P-NITROBENZOYL-L-GLUTAMIC ACID
4-Aminohippuric acid
P-AMINOHIPPURIC ACID SODIUM SALT
N-(p-Aminobenzoyl)glutamic acid
METHOTREXATE HYDRATE
5-METHYLTETRAHYDROFOLIC ACID DISODIUM SALT
diethyl N-[4-(methylamino)benzoyl]-L-glutamate
DIHYDROFOLIC ACID
N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID DIETHYL ESTER
4-NITROHIPPURIC ACID
(+/-)AMETHOPTERIN
P-AMINOHIPPURIC ACID SODIUM