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DIHYDROCYCLOSPORIN A

CAS No.
59865-15-5
Chemical Name:
DIHYDROCYCLOSPORIN A
Synonyms
CS-2523;Cyclosporin EP B;Dihydrocyclosporin;Capecitabine Imp.G;DIHYDROCYCLOSPORIN A;Dihydrocyclosporine A;Cyclosporin Impurity 10;Cyclosporine Impurity 10;Ciclosporin EP impurity B;Dihydrocyclosporin A reference
CBNumber:
CB5352728
Molecular Formula:
C62H113N11O12
Molecular Weight:
1204.63
MDL Number:
MFCD08458303
MOL File:
59865-15-5.mol
MSDS File:
SDS
Last updated:2023-09-06 15:55:14

DIHYDROCYCLOSPORIN A Properties

Melting point 120-125?C
Boiling point 1285.3±65.0 °C(Predicted)
Density 1.012±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Solid
pka 13.33±0.70(Predicted)
color White
InChIKey TYFOVYYNQGNDKH-AAJDKDKZNA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H350-H302-H362
Precautionary statements  P264-P270-P301+P312-P330-P501-P201-P260-P263-P264-P270-P308+P313

DIHYDROCYCLOSPORIN A price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D448865 DihydroCyclosporinA 59865-15-5 5mg $130 2021-12-16 Buy
Usbiological D3801-01 Dihydrocyclosporin A 59865-15-5 1mg $362 2021-12-16 Buy
TRC D448865 DihydroCyclosporinA 59865-15-5 100mg $1480 2021-12-16 Buy
American Custom Chemicals Corporation API0002365 DIHYDROCYCLOSPORIN A 95.00% 59865-15-5 100MG $1732.5 2021-12-16 Buy
Biosynth Carbosynth FD21913 Dihydrocyclosporin A 59865-15-5 25mg $700 2021-12-16 Buy
Product number Packaging Price Buy
D448865 5mg $130 Buy
D3801-01 1mg $362 Buy
D448865 100mg $1480 Buy
API0002365 100MG $1732.5 Buy
FD21913 25mg $700 Buy

DIHYDROCYCLOSPORIN A Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Dihydrocyclosporin A (DHCsA-d) is cyclosporine A (CsA) derivative. DHCsA-d significantly inhibited promastigotes and intracellular amastigotes, but it is highly cytotoxic.

Uses

Dihydrocyclosporin A is a closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A possesses no immunosuppressant activity and has found use as a control to determine the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections.

Uses

A Cyclosporin A (C988900) analog, an immunosuppressant.

Side effects

Dihydrocyclosporine A has no obvious nephrotoxic effect, but it exhibits hepatotoxic effects, often leading to hypertension.

59865-13-3
59865-15-5
Synthesis of DIHYDROCYCLOSPORIN A from Cyclosporin A

DIHYDROCYCLOSPORIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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DIHYDROCYCLOSPORIN A Spectrum

DIHYDROCYCLOSPORIN A Dihydrocyclosporin (3R,4R)-3-Hydroxy-4,N-dimethyl-5-propylcyclo[L-Nva-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-] (3R,4R)-3-Hydroxy-N-methyl-5-propylcyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-) 6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A Cyclosporin A Dihydro IMpurity Dihydrocyclosporine A Cyclosporin Impurity 10 Dihydrocyclosporin A reference Dihydrocyclosporine A/6-[(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)octanoic acid]cyclosporin A CS-2523 Cyclosporin Impurity 10(Dihydrocyclosporin A) Cyclosporin A,6-[(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)octanoic acid]- Capecitabine Imp.G Cyclosporine Impurity 10 Ciclosporin EP impurity B Cyclosporin Impurity 10(Dihydrocyclosporin A)(Ciclosporin EP Impurity B) Ciclosporin EP Impurity B (Dihydrocyclosporin A) Cyclosporin EP B 59865-15-5 C62H113N11O12 Intermediates & Fine Chemicals Peptides Pharmaceuticals