HUMAN MIP-1ALPHA
- CAS No.
- Chemical Name:
- HUMAN MIP-1ALPHA
- Synonyms
- MIP-1ALPHA;HUMAN CCL3;RHMIP-1ALPHA;MIP-1A, HUMAN;HUMAN MIP-1ALPHA;HUMAN LD78 ALPHA;TY-5, SIS-αMIP-1ALPHA, HUMAN;REC MIP-1A (HUMAN);MIP1A [HOMO SAPIENS]
- CBNumber:
- CB5359257
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00213004
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Hazard Codes | T |
|---|---|
| Risk Statements | 23/24/25-36/37/38 |
| Safety Statements | 26-36/37/39-45 |
| WGK Germany | 3 |
HUMAN MIP-1ALPHA price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP4244 | MIP-1alpha human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC) | 20μg | $351 | 2023-06-20 | Buy | |
| Usbiological | M1202-06A | Macrophage Inflammatory Protein-1 Alpha | 10ug | $460 | 2021-12-16 | Buy | |
| Usbiological | M1202-01 | Macrophage Inflammatory Protein 1 alpha | 100ug | $754 | 2021-12-16 | Buy |
HUMAN MIP-1ALPHA Chemical Properties,Uses,Production
General Description
MIP-1α (microphage inflammatory protein-1α), or CCL3 (C-C motif chemokine ligand 3), was originally isolated from the supernatant of endotoxin-stimulated murine macrophages. It is an 8kDa chemokine; chemokines are a type of chemotactic cytokines.
Biochem/physiol Actions
MIP-1α (microphage inflammatory protein-1α), or CCL3 (C-C motif chemokine ligand 3), and its receptors- CCR1 and CCR5- promote tumor growth and control osteoclast differentiation, thereby contributing to bone disease progression in multiple myeloma. It suppresses the expression of miR-374b through JNK (Janus kinase), ERK (extracellular signal-regulated kinases), and p38 pathways, thus, facilitating VEGF-A (vascular endothelial growth factor) expression and angiogenesis in human osteosarcoma cells. In chondrosarcoma cells, this protein promotes the up-regulation of matrix metalloproteinase-2 (MMP)-2, thus, promoting cell migration and metastasis.
HUMAN MIP-1ALPHA Preparation Products And Raw materials
Raw materials
Preparation Products
HUMAN MIP-1ALPHA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| Chemsky (shanghai) International Co.,Ltd | 60 |
| United States Biological | 58 |