HUMAN MIP-1ALPHA

HUMAN MIP-1ALPHA 구조식 이미지
카스 번호:
상품명:
HUMAN MIP-1ALPHA
동의어(영문):
MIP-1ALPHA;HUMAN CCL3;RHMIP-1ALPHA;MIP-1A, HUMAN;HUMAN MIP-1ALPHA;HUMAN LD78 ALPHA;TY-5, SIS-αMIP-1ALPHA, HUMAN;REC MIP-1A (HUMAN);MIP1A [HOMO SAPIENS]
CBNumber:
CB5359257
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

HUMAN MIP-1ALPHA 속성

저장 조건
−20°C
물리적 상태
동결건조된 분말

안전

위험품 표기 T
위험 카페고리 넘버 23/24/25-36/37/38
안전지침서 26-36/37/39-45
WGK 독일 3

HUMAN MIP-1ALPHA C화학적 특성, 용도, 생산

일반 설명

MIP-1α (microphage inflammatory protein-1α), or CCL3 (C-C motif chemokine ligand 3), was originally isolated from the supernatant of endotoxin-stimulated murine macrophages. It is an 8kDa chemokine; chemokines are a type of chemotactic cytokines.

Biochem/physiol Actions

MIP-1α (microphage inflammatory protein-1α), or CCL3 (C-C motif chemokine ligand 3), and its receptors- CCR1 and CCR5- promote tumor growth and control osteoclast differentiation, thereby contributing to bone disease progression in multiple myeloma. It suppresses the expression of miR-374b through JNK (Janus kinase), ERK (extracellular signal-regulated kinases), and p38 pathways, thus, facilitating VEGF-A (vascular endothelial growth factor) expression and angiogenesis in human osteosarcoma cells. In chondrosarcoma cells, this protein promotes the up-regulation of matrix metalloproteinase-2 (MMP)-2, thus, promoting cell migration and metastasis.

HUMAN MIP-1ALPHA 준비 용품 및 원자재

원자재

준비 용품


HUMAN MIP-1ALPHA 공급 업체

글로벌( 24)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15421 60
United States Biological --
sales@advtechind.com United States 6106 58

Copyright 2019 © ChemicalBook. All rights reserved