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ENALAPRILAT DIHYDRATE

CAS No.
84680-54-6
Chemical Name:
ENALAPRILAT DIHYDRATE
Synonyms
MK-422;ENALAPRILATE;as dihydrate;ENALAPRILAT USP;MK-422 Dihydrate;Enalaprilate USP25;Vasotec IV Dihydrate;Enalaprilat (300 mg);ENALAPRILAT DIHYDRATE;Enalaprilat (1235274)
CBNumber:
CB5373019
Molecular Formula:
C18H26N2O6
Molecular Weight:
366.41
MDL Number:
MFCD00941393
MOL File:
84680-54-6.mol
MSDS File:
SDS
Last updated:2024-11-11 20:33:26

ENALAPRILAT DIHYDRATE Properties

Melting point 151-159°C
alpha [α]D25 -53.0~-56.0゜ (c=1, CH3OH) (Calculated on dehydrous basis)
storage temp. 2-8°C
solubility H2O: soluble14mg/mL at 60°C (warming for 5 minutes)
form Solid
color White to Off-White
CAS DataBase Reference 84680-54-6(CAS DataBase Reference)
FDA UNII GV0O7ES0R3
EPA Substance Registry System L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-, hydrate (1:2) (84680-54-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
WGK Germany  3
RTECS  TW3590600
HS Code  2933995300
NFPA 704
0
2 0

ENALAPRILAT DIHYDRATE price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E9658 Enalaprilat dihydrate ≥98% (HPLC) 84680-54-6 5mg $134 2024-03-01 Buy
Sigma-Aldrich 1235274 Enalaprilat United States Pharmacopeia (USP) Reference Standard 84680-54-6 300mg $519 2024-03-01 Buy
Sigma-Aldrich BP742 Enalaprilat British Pharmacopoeia (BP) Reference Standard 84680-54-6 20MG $227 2023-06-20 Buy
TCI Chemical E1302 Enalaprilat Dihydrate >98.0%(HPLC) 84680-54-6 50mg $122 2024-03-01 Buy
TCI Chemical E1302 Enalaprilat Dihydrate >98.0%(HPLC) 84680-54-6 250mg $363 2022-04-27 Buy
Product number Packaging Price Buy
E9658 5mg $134 Buy
1235274 300mg $519 Buy
BP742 20MG $227 Buy
E1302 50mg $122 Buy
E1302 250mg $363 Buy

ENALAPRILAT DIHYDRATE Chemical Properties,Uses,Production

Description

Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril , an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.

Chemical Properties

White Solid

Uses

Active metabolite of Enalapril. A nonsulfhydryl dipeptide angiotensin converting enzyme (ACE) inhibitor. Enalapril EP Impurity C (Dihydrate).

Uses

anthelmintic

Definition

ChEBI: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients wi h nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.

Biochem/physiol Actions

Enalapril, the ethyl ester of?enalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver to?enalaprilat. Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.

ENALAPRILAT DIHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 175)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20288 58
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29885 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14332 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
TopScience Biochemical
00852-68527855 info@itopbiochem.com China Hong Kong 902 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32079 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15354 58

View Lastest Price from ENALAPRILAT DIHYDRATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Enalaprilat Dihydrate pictures 2024-11-14 Enalaprilat Dihydrate
84680-54-6
US $0.00 / g/Bag 1g 98%-101% 500G WUHAN FORTUNA CHEMICAL CO., LTD
Enalaprilat Dihydrate pictures 2024-11-11 Enalaprilat Dihydrate
84680-54-6
US $33.00-84.00 / mg 99.78% 10g TargetMol Chemicals Inc.
ENALAPRILAT DIHYDRATE pictures 2024-04-15 ENALAPRILAT DIHYDRATE
84680-54-6
US $32.00-1.30 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

ENALAPRILAT DIHYDRATE Spectrum

(S)-1-[N-[1-(CARBOXY)-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE, DIHYDRATE MK-422 ENALAPRILAT DIHYDRATE ENALAPRILATE Enalaprilate USP25 ENALAPRILAT USP Enalaprilat (300 mg) Enalaprilic Acid Dihydrate MK-422 Dihydrate Vasotec IV Dihydrate Enalapril Maleate IMpurity–C(EP) Enalapril EP IMpurity C L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-, dihydrate, (S)- (9CI) N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline, hydrate (1:2) Enalaprilat dihydrate, >=99% as dihydrate Enalaprilat for system suitability CRS Enalaprilat dihydrate CRS ENALAPRILAT DIHYDRATE USP/EP/BP Enalaprilat (1235274) (S)-1-((S)-2-(((S)-1-Carboxy-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid dihydrate Enalapril EP Impurity C(Hydrate) 84680-54-6 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Inhibitors