RO6889678
- CAS No.
- 1578153-27-1
- Chemical Name:
- RO6889678
- Synonyms
- RO6889678;3-Morpholinecarboxylic acid, 4-[[(6R)-6-(2-chloro-4-fluorophenyl)-3,6-dihydro-5-(methoxycarbonyl)-2-(2-thiazolyl)-4-pyrimidinyl]methyl]-, (3S)-;inhibit,Hepatitis B virus,coregulated protein,UDP-glucuronosyltransferase,HB capsid formation,ADME,CYP3A4,RO-6889678,RO6889678,hepatocytes,CYPs,Cytochrome P450,UGT1A3,oxidation,RO 6889678,HBV,UGT1A1,Inhibitor,glucuronidation
- CBNumber:
- CB54668452
- Molecular Formula:
- C21H20ClFN4O5S
- Molecular Weight:
- 494.92
- MDL Number:
- MFCD30802197
- MOL File:
- 1578153-27-1.mol
RO6889678 Chemical Properties,Uses,Production
Description
RO6889678 is an inhibitor of HBV with a complex ADME profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 μl/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 μl/min per mg protein, respectively. The induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction.
in vitro
RO6889678 is a highly potent inhibitor of HBV capsid formation, with attributes that are favorable for targeting the liver while maintaining moderate peripheral exposure._x000D_ _x000D_ Reference: J Pharmacol Exp Ther. 2018 May;365(2):237-248. https://pubmed.ncbi.nlm.nih.gov/29453199/
target
RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes.
RO6889678 Preparation Products And Raw materials
Raw materials
Preparation Products
RO6889678 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Guangyang Jiali Biotechnology Co., Ltd | 13407521611 | 46993711@qq.com | China | 176 | 58 |
| Shanghai meikai technology co., ltd | 021-18721550-091 18721550091 | yangdong@pharma.com | China | 4123 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3616 | 58 |
| Wuhan Topule | +86-02787215551 +86-19945035818 | 2936752263@qq.com | China | 8233 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2881924765@qq.com | China | 7972 | 58 |
| Shanghai Guangyang Carrie Biotechnology Co., LTD | 18616826356 | 1942593824@qq.com | China | 1090 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6749 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |