ChemicalBook CAS DataBase List RO6889678

RO6889678 synthesis

8synthesis methods

Product Name:RO6889678
CAS Number:1578153-27-1
Molecular formula:C21H20ClFN4O5S
Molecular Weight:494.92

3-Morpholinecarboxylic acid, 4-[[6-(2-chloro-4-fluorophenyl)-3,6-dihydro-5-(methoxycarbonyl)-2-(2-thiazolyl)-4-pyrimidinyl]methyl]-, (3S)-

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1578153-27-1
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Yield:1578153-27-1 94%

Reaction Conditions:

in tert-butyl methyl ether at 20; for 4 h;Solvent;

Steps:

1 Example 1:(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydrogen Pyrimidin-4-yl)methyl)morpholine-3-carboxylic acid Preparation

(25S)-4-((6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6) was sequentially added to a 25 mL jar. -dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid (1 g) and ethanol (5 mL),The mixture was stirred at room temperature for 4 hours and filtered.The filtrate is concentrated under reduced pressure to remove the solvent.Obtained (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-di Hydroxymidin-4-yl)methyl)morpholine-3-carboxylic acid was a yellow foamy solid (0.46 g, 92%).Chiral purity 95%.

References:

CN107674072,2018,A Location in patent:Paragraph 0199; 0200; 0201; 0206; 0207