NOMIFENSINE MALEATE
- CAS No.
- 24526-64-5
- Chemical Name:
- NOMIFENSINE MALEATE
- Synonyms
- linamiphen;Nomifensin;Nomifenison;NOMIFENSINE MALEATE USP/EP/BP;Dopamine Receptor,Inhibitor,Nomifensine,inhibit;1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin;2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine;2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine;8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline;8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline
- CBNumber:
- CB5503980
- Molecular Formula:
- C16H18N2
- Molecular Weight:
- 238.33
- MDL Number:
- MFCD00242716
- MOL File:
- 24526-64-5.mol
- MSDS File:
- SDS
| Melting point | 179-181° |
|---|---|
| Boiling point | 370.93°C (rough estimate) |
| Density | 0.9597 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): Partially soluble |
| form | A crystalline solid |
| pka | 7.85±0.40(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | 1LGS5JRP31 |
| EPA Substance Registry System | Nomifensine (24526-64-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NX4912800 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Hazardous Substances Data | 24526-64-5(Hazardous Substances Data) | |||||||||
| Toxicity | TDLo orl-wmn: 7 mg/kg/7D-I:BLD BMJOAE 288,830,84 | |||||||||
| NFPA 704 |
|
NOMIFENSINE MALEATE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29330 | Nomifensine | 24526-64-5 | 25mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 29330 | Nomifensine | 24526-64-5 | 50mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 29330 | Nomifensine | 24526-64-5 | 100mg | $138 | 2024-03-01 | Buy |
| ChemScene | CS-4708 | Nomifensine 98.93% | 24526-64-5 | 100mg | $192 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0299991 | 2-METHYL-4-PHENYL-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-8-YLAMINE 95.00% | 24526-64-5 | 500MG | $679.14 | 2021-12-16 | Buy |
NOMIFENSINE MALEATE Chemical Properties,Uses,Production
Description
Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake. It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC50 values of 6.6, 48, and 830 nM, respectively. It is selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D2, α1- adrenergic-, 5-HT2, and muscarinic receptors (IC50s = 43,000, 1,200, 3,800, and >13,000 nM, respectively, in rat brain membranes). Nomifensine is selective for inhibition of NE over DA uptake in vivo with minimal inhibitory doses of 28 and less than 57 μmol/kg, respectively. It decreases the time Wistar Kyoto, but not Sprague-Dawley, rats spend immobile in the forced swim test but also increases locomotor activity in the open field test in Wistar Kyoto and Sprague-Dawley rats when administered at a chronic dose of 10 mg/kg.
Originator
Alival,Hoechst,W. Germany ,1976
Uses
A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.
Definition
ChEBI: An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Manufacturing Process
A solution of N-(2-aminobenzyl)-1-phenyl-2-methylaminoethanol-1 was prepared by the reaction of α-bromo-acetophenone and (2nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickel on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. By extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-isoquinoline. The base is reacted with maleic acid to give the maleate; melting point of the maleate 199° to 201°C (from ethanol).
brand name
Merital (Hoechst-Roussel);Anametrin;Caribium;Hoe 984;Hostalival;Merival;Musettamycin;Neurolene;Nomival;Psicronizer;Psyton.
Therapeutic Function
Psychostimulant
World Health Organization (WHO)
Nomifensine, an antidepressant indicated for the treatment of a wide range of depressive illness, was introduced in 1976. Subsequently rare cases of haemolytic anaemia - sometimes fatal - thrombocytopenia, hepatotoxicity and fever were associated with the use of the drug. Following discussions with regulatory authorities in the United Kingdom and the Federal Republic of Germany the major manufacturer withdrew all preparations containing nomifensine worldwide in January 1986.
Safety Profile
Poison by ingestion andintravenous routes. Human systemic effects by ingestion:diffuse hepatitis, hemorrhage and decrease in the numberof blood platelets (thrombocytopenia). When heated todecomposition it emits toxic fumes of NOx.
NOMIFENSINE MALEATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18750 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22787 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Xuzhou B&C Chemical Co.,Ltd | +86-400-0516-021 | info@bcpharma.com | China | 2738 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
View Lastest Price from NOMIFENSINE MALEATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Nomifensine
24526-64-5
|
US $30.00-64.00 / mg | ≥95% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-27 | NOMIFENSINE MALEATE USP/EP/BP
24526-64-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | NOMIFENSINE MALEATE
24526-64-5
|
US $1.00 / KG | 1KG | 99% | 1000KG | Career Henan Chemical Co |
-
- Nomifensine
24526-64-5
- US $30.00-64.00 / mg
- ≥95%
- TargetMol Chemicals Inc.
-
- NOMIFENSINE MALEATE USP/EP/BP
24526-64-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- NOMIFENSINE MALEATE
24526-64-5
- US $1.00 / KG
- 99%
- Career Henan Chemical Co