6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE
- CAS No.
- 167423-51-0
- Chemical Name:
- 6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE
- Synonyms
- TIMTEC-BB SBB003270;GIHYTRGUZVYCQX-RFKZQXLXSA-N;6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE;2-AMINO-5,6,7,8-TETRAHYDRO-CIS-6,7-DIMETHYL-4(1H)-PTERIDINONE HYDROCHLORIDE
- CBNumber:
- CB5764004
- Molecular Formula:
- C8H14ClN5O
- Molecular Weight:
- 231.68
- MDL Number:
- MFCD00672620
- MOL File:
- 167423-51-0.mol
6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 81040 | 6,7-Dimethyltetrahydropterin (hydrochloride) ≥99% | 167423-51-0 | 10mg | $14 | 2022-04-27 | Buy |
Cayman Chemical | 81040 | 6,7-Dimethyltetrahydropterin (hydrochloride) ≥99% | 167423-51-0 | 50mg | $59 | 2022-04-27 | Buy |
Cayman Chemical | 81040 | 6,7-Dimethyltetrahydropterin (hydrochloride) ≥99% | 167423-51-0 | 100mg | $104 | 2022-04-27 | Buy |
Cayman Chemical | 81040 | 6,7-Dimethyltetrahydropterin (hydrochloride) ≥99% | 167423-51-0 | 500mg | $454 | 2022-04-27 | Buy |
American Custom Chemicals Corporation | CHM0149490 | 2-AMINO-5,6,7,8-TETRAHYDRO-CIS-6,7-DIMETHYL-4(1H)-PTERIDINONE HYDROCHLORIDE 95.00% | 167423-51-0 | 5MG | $504.46 | 2021-12-16 | Buy |
6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Chemical Properties,Uses,Production
Biological Activity
6,7-dimethyltetrahydropterin is a gtp cyclohydrolase i inhibitor.gtp cyclohydrolase i catalyzes the formation of d-erythro-7,8-dihydroneopterin (dihydroneopterin) triphosphate and formate from gtp. dihydroneopterin triphosphate has been identified as a critical intermediate in the biosynthesis of folic acid, pteridines in insects and amphibians, and tetrahydrobiopterin. tetrahydrobiopterin is the obligatory cofactor for tyrosine and tryptophan hydroxylase, which are rate-limiting enzymes for biogenic amine synthesis. tetrahydrobiopterin is the cofactor for phenylalanine hydroxylase as well, which converts lphenylalanine to l-tyrosine.
in vitro
previous study identified 6,7-dimethyltetrahydropterin as a noncompetitive inhibitor of gtp cyclohydrolase. however, no substrate inhibition of the enzyme was detected 1mm gtp, which is about 8-fold the km value of the enzyme [1]. another study found that phenylalanine hydroxylase could be inhibited by 6,7-dimethyltetrahydropterin, its cofactor. the rate of inactivation, which was irreversible, increased with the concentration of 6,7-dimethyltetrahydropterin. moreover, 6,7-dimethyltetrahydropterin was found to be unstable when the solution was exposed to air but was stabilized by dithiothreitol the aerobic oxidation of which was significantly accelerated by 6,7-dimethyltetrahydropterin [2].
IC 50
76-112 μm for gtp cyclohydrolase i
References
[1] shen, r. ,alam, a. and zhang, y. inhibition of gtp cyclohydrolase i by pterins. biochimica et biophysica acta 965, 9-15 (1988).
[2] jakubovic a, woolf li, chan-henry e. the inactivation of phenylalanine hydroxylase by 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine and the aerobic oxidation of the latter. the effects of catalase, dithiothreitol and reduced nicotinamide-adenine dinucleotide. biochem j. 1971 nov;125(2):563-8.
6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Supplier | Advantage |
---|---|
Aladdin Scientific | 58 |
BOC Sciences | 65 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
MedBioPharmaceutical Technology Inc | 58 |
ApexBio Technology | 58 |