ChemicalBook >> CAS DataBase List >>6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE

6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE

CAS No.
167423-51-0
Chemical Name:
6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE
Synonyms
TIMTEC-BB SBB003270;GIHYTRGUZVYCQX-RFKZQXLXSA-N;6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE;2-AMINO-5,6,7,8-TETRAHYDRO-CIS-6,7-DIMETHYL-4(1H)-PTERIDINONE HYDROCHLORIDE
CBNumber:
CB5764004
Molecular Formula:
C8H14ClN5O
Molecular Weight:
231.68
MDL Number:
MFCD00672620
MOL File:
167423-51-0.mol
Last updated:2023-05-21 10:59:17

6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Properties

storage temp. Store at -20°C
solubility Soluble in H2O
form crystalline solid

6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 81040 6,7-Dimethyltetrahydropterin (hydrochloride) ≥99% 167423-51-0 10mg $14 2022-04-27 Buy
Cayman Chemical 81040 6,7-Dimethyltetrahydropterin (hydrochloride) ≥99% 167423-51-0 50mg $59 2022-04-27 Buy
Cayman Chemical 81040 6,7-Dimethyltetrahydropterin (hydrochloride) ≥99% 167423-51-0 100mg $104 2022-04-27 Buy
Cayman Chemical 81040 6,7-Dimethyltetrahydropterin (hydrochloride) ≥99% 167423-51-0 500mg $454 2022-04-27 Buy
American Custom Chemicals Corporation CHM0149490 2-AMINO-5,6,7,8-TETRAHYDRO-CIS-6,7-DIMETHYL-4(1H)-PTERIDINONE HYDROCHLORIDE 95.00% 167423-51-0 5MG $504.46 2021-12-16 Buy
Product number Packaging Price Buy
81040 10mg $14 Buy
81040 50mg $59 Buy
81040 100mg $104 Buy
81040 500mg $454 Buy
CHM0149490 5MG $504.46 Buy

6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Chemical Properties,Uses,Production

Biological Activity

6,7-dimethyltetrahydropterin is a gtp cyclohydrolase i inhibitor.gtp cyclohydrolase i catalyzes the formation of d-erythro-7,8-dihydroneopterin (dihydroneopterin) triphosphate and formate from gtp. dihydroneopterin triphosphate has been identified as a critical intermediate in the biosynthesis of folic acid, pteridines in insects and amphibians, and tetrahydrobiopterin. tetrahydrobiopterin is the obligatory cofactor for tyrosine and tryptophan hydroxylase, which are rate-limiting enzymes for biogenic amine synthesis. tetrahydrobiopterin is the cofactor for phenylalanine hydroxylase as well, which converts lphenylalanine to l-tyrosine.

in vitro

previous study identified 6,7-dimethyltetrahydropterin as a noncompetitive inhibitor of gtp cyclohydrolase. however, no substrate inhibition of the enzyme was detected 1mm gtp, which is about 8-fold the km value of the enzyme [1]. another study found that phenylalanine hydroxylase could be inhibited by 6,7-dimethyltetrahydropterin, its cofactor. the rate of inactivation, which was irreversible, increased with the concentration of 6,7-dimethyltetrahydropterin. moreover, 6,7-dimethyltetrahydropterin was found to be unstable when the solution was exposed to air but was stabilized by dithiothreitol the aerobic oxidation of which was significantly accelerated by 6,7-dimethyltetrahydropterin [2].

IC 50

76-112 μm for gtp cyclohydrolase i

References

[1] shen, r. ,alam, a. and zhang, y. inhibition of gtp cyclohydrolase i by pterins. biochimica et biophysica acta 965, 9-15 (1988).
[2] jakubovic a, woolf li, chan-henry e. the inactivation of phenylalanine hydroxylase by 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine and the aerobic oxidation of the latter. the effects of catalase, dithiothreitol and reduced nicotinamide-adenine dinucleotide. biochem j. 1971 nov;125(2):563-8.

6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Suppliers

Global( 11)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
ApexBio Technology -- sales@apexbt.com United States 6254 58
6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE 2-AMINO-5,6,7,8-TETRAHYDRO-CIS-6,7-DIMETHYL-4(1H)-PTERIDINONE HYDROCHLORIDE TIMTEC-BB SBB003270 GIHYTRGUZVYCQX-RFKZQXLXSA-N 167423-51-0 Miscellaneous Natural Products