batroxostatin
- CAS No.
- 130357-67-4
- Chemical Name:
- batroxostatin
- Synonyms
- batroxostatin
- CBNumber:
- CB61355170
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
batroxostatin Chemical Properties,Uses,Production
Enzyme inhibitor
This cysteine-rich, 71-residue disintegrin (MW = 7602.46 g/mol; CAS 130357-67-4), from the snake Bothrops atrox (Barba amarilla) contains an RGD loop that facilitates high-affinity binding to integrins in a manner that inhibits ADP-induced platelet aggregation (IC50 = 133 nM), about 1000- times higher than that of Arg-Gly-Asp-Ser tetrapeptide. In addition, batroxostatin was about 400-times more potent than Arg-Gly-Asp-Ser at inhibiting melanoma cell adhesion to fibronectin. When covalently attached to plastic culture dishes, batroxostatin promoted adhesion of melanoma cells.
batroxostatin Preparation Products And Raw materials
Raw materials
Preparation Products
batroxostatin
130357-67-4