ARV-393
- CAS No.
- 2851885-95-3
- Chemical Name:
- ARV-393
- Synonyms
- ARV393;Acetamide, 2-[[6-[[5-chloro-2-[4-[[trans-3-[4-[2-(2,6-dioxo-3-piperidinyl)-4-fluoro-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-piperidinyl]cyclobutyl]oxy]-1-piperidinyl]-4-pyrimidinyl]amino]-1,2-dihydro-1-(1-methylethyl)-2-oxo-3-quinolinyl]oxy]-N-methyl-
- CBNumber:
- CB614032026
- Molecular Formula:
- C46H53ClFN9O7
- Molecular Weight:
- 898.42
- MDL Number:
- MOL File:
- 2851885-95-3.mol
ARV-393 Chemical Properties,Uses,Production
Description
ARV-393 is an orally active proteolysis-targeting chimera (PROTAC) that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. It consists of ligand conjugates that target BCL6 and the E3 ligase cereblon, respectively. ARV-393 has demonstrated DC50 and GI50 values of less than 1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Additionally, it has shown considerable tumor suppressor activity in tumor xenograft models. ARV-393 is currently being studied for its potential to inhibit non-Hodgkin lymphoma.
Biological Functions
ARV-393 is an investigational PROTAC designed to degrade B-cell lymphoma 6 protein (BCL6), a transcriptional repressor and major driver of B-cell lymphomas. The BCL6 protein facilitates B cell tolerance of rapid proliferation and somatic gene recombination via repressing cell cycle checkpoints, terminal differentiation, apoptosis, and the DNA damage response.
target
BCL6
ARV-393 Preparation Products And Raw materials
Raw materials
Preparation Products
ARV-393 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Chuchang Biotech Co., Ltd. | +undefined15623860702 | info@chuchangbiotech.com | China | 111 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4578 | 58 |
| Hubei Chuchang Chemical Co., Ltd | 15623560702 | Joy.Ren@aliyun.com | China | 145 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4287 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8017 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9941 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 994 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3715 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15342225168 | yutianchun2007@126.com | China | 10008 | 58 |
