ARV-393

2851885-95-3

CAS番号.: 2851885-95-3

化学名:

别名:

英語名:: ARV-393

英語别名:: ARV393;Acetamide, 2-[[6-[[5-chloro-2-[4-[[trans-3-[4-[2-(2,6-dioxo-3-piperidinyl)-4-fluoro-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-piperidinyl]cyclobutyl]oxy]-1-piperidinyl]-4-pyrimidinyl]amino]-1,2-dihydro-1-(1-methylethyl)-2-oxo-3-quinolinyl]oxy]-N-methyl-

CBNumber:: CB614032026

化学式:: C46H53ClFN9O7

分子量:: 898.42

MOL File:: 2851885-95-3.mol

物理性質

安全性情報

用途語

生産企業 16

ARV-393 物理性質

比重(密度) :: 1.45±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

酸解離定数(Pka):: 10.63±0.40(predicted)

外見 :: Solid

色:: White to off-white

安全性情報

ARV-393 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

ARV-393 化学特性,用途語,生産方法

説明

ARV-393 is an orally active proteolysis-targeting chimera (PROTAC) that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. It consists of ligand conjugates that target BCL6 and the E3 ligase cereblon, respectively. ARV-393 has demonstrated DC50 and GI50 values of less than 1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Additionally, it has shown considerable tumor suppressor activity in tumor xenograft models. ARV-393 is currently being studied for its potential to inhibit non-Hodgkin lymphoma.

ARV-393 上流と下流の製品情報

原材料

準備製品

ARV-393 生産企業

Global( 16)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hubei Chuchang Biotech Co., Ltd.	+undefined15623860702	info@chuchangbiotech.com	China	111	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4578	58
Hubei Chuchang Chemical Co., Ltd	15623560702	Joy.Ren@aliyun.com	China	145	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3466	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4287	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8017	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9941	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	994	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3715	58
Chunchuang (Wuhan) Technology Co., Ltd	15342225168	yutianchun2007@126.com	China	10008	58

2851885-95-3
ARV393
Acetamide, 2-[[6-[[5-chloro-2-[4-[[trans-3-[4-[2-(2,6-dioxo-3-piperidinyl)-4-fluoro-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-piperidinyl]cyclobutyl]oxy]-1-piperidinyl]-4-pyrimidinyl]amino]-1,2-dihydro-1-(1-methylethyl)-2-oxo-3-quinolinyl]oxy]-N-methyl-