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ARV-393

ARV-393 구조식 이미지

카스 번호:: 2851885-95-3

상품명:: ARV-393

동의어(영문):: ARV393;2-((6-((5-Chloro-2-(4-(trans-3-(4-(2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)piperidin-1-yl)cyclobutoxy)piperidin-1-yl)pyrimidin-4-yl)amino)-1-isopropyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)-N-methylacetamide;2-({6-[(5-chloro-2-{4-[(1r,3r)-3-{4-[2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-2,3-dihydro-1H-isoindol-5-yl]piperidin-1-yl}cyclobutoxy]piperidin-1-yl}pyrimidin-4-yl)amino]-2-oxo-1-(propan-2-yl)-1,2-dihydroquinolin-3-yl}oxy)-N-methylacetamide;Acetamide, 2-[[6-[[5-chloro-2-[4-[[trans-3-[4-[2-(2,6-dioxo-3-piperidinyl)-4-fluoro-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-piperidinyl]cyclobutyl]oxy]-1-piperidinyl]-4-pyrimidinyl]amino]-1,2-dihydro-1-(1-methylethyl)-2-oxo-3-quinolinyl]oxy]-N-methyl-

CBNumber:: CB614032026

분자식:: C46H53ClFN9O7

포뮬러 무게:: 898.42

MOL 파일:: 2851885-95-3.mol

속성

안전

용도

공급 업체 18

ARV-393 속성

밀도: 1.45±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

산도 계수 (pKa): 10.63±0.40(predicted)

물리적 상태: Solid

색상: White to off-white

안전

ARV-393 C화학적 특성, 용도, 생산

개요

ARV-393 is an orally active proteolysis-targeting chimera (PROTAC) that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. It consists of ligand conjugates that target BCL6 and the E3 ligase cereblon, respectively. ARV-393 has demonstrated DC50 and GI50 values of less than 1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Additionally, it has shown considerable tumor suppressor activity in tumor xenograft models. ARV-393 is currently being studied for its potential to inhibit non-Hodgkin lymphoma.

ARV-393 준비 용품 및 원자재

원자재

준비 용품

ARV-393 공급 업체

글로벌( 18)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hubei Chuchang Biotech Co., Ltd.	+undefined15623860702	info@chuchangbiotech.com	China	111	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4679	58
Hubei Chuchang Chemical Co., Ltd	15623560702	Joy.Ren@aliyun.com	China	146	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3466	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4351	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8014	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9949	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	996	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3852	58
Chunchuang (Wuhan) Technology Co., Ltd	15342225168	yutianchun2007@126.com	China	10001	58