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Drinabant

CAS No.
358970-97-5
Chemical Name:
Drinabant
Synonyms
AVE-1625;drinabant;N-[1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl]-N-(3,5-difluorophenyl)methanesulfonamide;Methanesulfonamide, N-[1-[bis(4-chlorophenyl)methyl]-3-azetidinyl]-N-(3,5-difluorophenyl)-
CBNumber:
CB61518506
Molecular Formula:
C23H20Cl2F2N2O2S
Molecular Weight:
497.38
MDL Number:
MFCD10567084
MOL File:
358970-97-5.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

Drinabant Properties

Boiling point 581.7±60.0 °C(Predicted)
Density 1.458
storage temp. Store at -20°C
solubility ≤0.15mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide
form crystalline solid
pka 5.44±0.10(Predicted)
FDA UNII 61S98RLL5I

Drinabant price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10009021 AVE-1625 ≥98% 358970-97-5 1mg $62 2024-03-01 Buy
Cayman Chemical 10009021 AVE-1625 ≥98% 358970-97-5 5mg $270 2024-03-01 Buy
Cayman Chemical 10009021 AVE-1625 ≥98% 358970-97-5 10mg $477 2024-03-01 Buy
Tocris 6763 AVE1625 ≥98%(HPLC) 358970-97-5 10 $243 2021-12-16 Buy
TRC A794723 AVE-1625 358970-97-5 2.5mg $110 2021-12-16 Buy
Product number Packaging Price Buy
10009021 1mg $62 Buy
10009021 5mg $270 Buy
10009021 10mg $477 Buy
6763 10 $243 Buy
A794723 2.5mg $110 Buy

Drinabant Chemical Properties,Uses,Production

Description

The central cannabinoid (CB1) receptor is a G protein-coupled receptor that is widely distributed in the central nervous system and several peripheral tissues and binds the active component of cannabis, Δ9-tetrahydrocannabinol. Signaling through the CB1 receptor is implicated in attentional and working memory deficits as well as obesity. AVE-1625 is a highly potent, selective antagonist for the CB1 receptor with Ki values of 0.16-0.44 nM. At 1-3 mg/kg, AVE-1625 significantly improves the performance of rodents in working memory tasks. At 30 mg/kg, AVE-1625 reduces caloric intake by more than 50% of controls and significantly increases lipolysis from fat tissues and reduces hepatic glycogen levels in rodents.

Uses

AVE-1625 is a selective antagonist for the CB1 receptor.

storage

Store at -20°C

References

[1] borowsky b, stevens r, mark b, et al. ave1625, a cannabinoid cbi antagonist, as a co-treatment for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in animal models[c]//neuropsychopharmacology. macmillan building, 4 crinan st, london n1 9xw, england: nature publishing group, 2005, 30: s116-s117.
[2] herkenham m, lynn a b, little m d, et al. cannabinoid receptor localization in brain[j]. proceedings of the national academy of sciences, 1990, 87(5): 1932-1936.
[3] herling a w, gossel m, haschke g, et al. cb1 receptor antagonist ave1625 affects primarily metabolic parameters independently of reduced food intake in wistar rats[j]. american journal of physiology-endocrinology and metabolism, 2007, 293(3): e826-e832.

Drinabant Preparation Products And Raw materials

Raw materials

Preparation Products

Drinabant Suppliers

Global( 30)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49391 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
BOC Sciences -- info@bocsci.com USA 0 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Suzhou Meishi Biotechnology Co., Ltd. 1173954148q meishipharma@126.com China 20035 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4249 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
ApexBio Technology -- sales@apexbt.com United States 6254 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
drinabant N-[1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl]-N-(3,5-difluorophenyl)methanesulfonamide AVE-1625 Methanesulfonamide, N-[1-[bis(4-chlorophenyl)methyl]-3-azetidinyl]-N-(3,5-difluorophenyl)- 358970-97-5 C23H20Cl2F2N2O2S