드리나반트

드리나반트
드리나반트 구조식 이미지
카스 번호:
358970-97-5
한글명:
드리나반트
동의어(한글):
드리나반트
상품명:
Drinabant
동의어(영문):
AVE-1625;drinabant;N-[1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl]-N-(3,5-difluorophenyl)methanesulfonamide;Methanesulfonamide, N-[1-[bis(4-chlorophenyl)methyl]-3-azetidinyl]-N-(3,5-difluorophenyl)-
CBNumber:
CB61518506
분자식:
C23H20Cl2F2N2O2S
포뮬러 무게:
497.38
MOL 파일:
358970-97-5.mol

드리나반트 속성

끓는 점
581.7±60.0 °C(Predicted)
밀도
1.458
저장 조건
Store at -20°C
용해도
≤0.15mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide
물리적 상태
결정질 고체
산도 계수 (pKa)
5.44±0.10(Predicted)
색상
White to off-white

안전

드리나반트 C화학적 특성, 용도, 생산

개요

The central cannabinoid (CB1) receptor is a G protein-coupled receptor that is widely distributed in the central nervous system and several peripheral tissues and binds the active component of cannabis, Δ9-tetrahydrocannabinol. Signaling through the CB1 receptor is implicated in attentional and working memory deficits as well as obesity. AVE-1625 is a highly potent, selective antagonist for the CB1 receptor with Ki values of 0.16-0.44 nM. At 1-3 mg/kg, AVE-1625 significantly improves the performance of rodents in working memory tasks. At 30 mg/kg, AVE-1625 reduces caloric intake by more than 50% of controls and significantly increases lipolysis from fat tissues and reduces hepatic glycogen levels in rodents.

드리나반트 준비 용품 및 원자재

원자재

준비 용품


드리나반트 공급 업체

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