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STATIL

STATIL structure

CAS No.: 72702-95-5

Chemical Name:: STATIL

Synonyms: STATIL;MK-538;ICI-plc;ICI-128436;Ponalrestat;Ponalrestat (MK-538;Ponalrestat - Bio-X ?;Ponalrestat, 10 mM in DMSO;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID;Ponalrestat Statil

CBNumber:: CB6193847

Molecular Formula:: C17H12BrFN2O3

Molecular Weight:: 391.19

MDL Number:: MFCD00204117

MOL File:: 72702-95-5.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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STATIL Properties

Melting point	184-186℃ (DEC.)
Density	1.60
storage temp.	Store at RT
solubility	DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL
form	A crystalline solid
color	White to off-white
FDA UNII	2CV0A5G64E
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Risk Statements	36/37/38
Safety Statements	26-36/37/39

STATIL price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	19189	Statil ≥98%	72702-95-5	5mg	$32	2024-03-01	Buy
Cayman Chemical	19189	Statil ≥98%	72702-95-5	10mg	$57	2024-03-01	Buy
Cayman Chemical	19189	Statil ≥98%	72702-95-5	25mg	$116	2024-03-01	Buy
Cayman Chemical	19189	Statil ≥98%	72702-95-5	50mg	$139	2024-03-01	Buy
TRC	S684550	Statil	72702-95-5	25mg	$95	2021-12-16	Buy

Product number	Packaging	Price	Buy
19189	5mg	$32	Buy
19189	10mg	$57	Buy
19189	25mg	$116	Buy
19189	50mg	$139	Buy
S684550	25mg	$95	Buy

STATIL Chemical Properties,Uses,Production

Description

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with K_i values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F_2α by human cultured preadipocytes.

Uses

Inhibitor (aldose reductase).

Uses

Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth

Definition

ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.

Biological Activity

Potent aldose reductase inhibitor.

in vivo

Ponalrestat (ICI 128436; 10, 50 mg/kg; orally; daily; 8 weeks) reduces sorbitol accumulation indicating efficacy of aldose reductase inhibition^[3].

Animal Model:	Adult female Sprague-Dawley rats^[3]
Dosage:	10, 50 mg/kg
Administration:	Orally; daily; 8 weeks
Result:	Reduced sorbitol accumulation.

STATIL synthesis

Synthesis of STATIL from 4-Bromo-2-fluorobenzyl bromide and (4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID ETHYL ESTER

STATIL Preparation Products And Raw materials

Raw materials

4-Bromo-2-fluorobenzyl bromide (4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID ETHYL ESTER

Preparation Products

STATIL Suppliers

Global( 97)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
Henan Alfa Chemical Co., Ltd	+8615838112936	alfa10@alfachem.cn	China	13194	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Henan Alfa Chemical Co., Ltd	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58

View Lastest Price from STATIL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Ponalrestat 72702-95-5	US $39.00-62.00 / mg		99.86%	10g	TargetMol Chemicals Inc.
	2019-12-25	STATIL;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID; 72702-95-5	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

Ponalrestat
72702-95-5
US $39.00-62.00 / mg
99.86%
TargetMol Chemicals Inc.

STATIL;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID;
72702-95-5
US $1.00 / KG
99%
Career Henan Chemical Co

72702-95-5(STATIL)Related Search:

STATIL BENZYL-(2-FLUORO-BENZYL)-AMINE 4-BROMO-2-FLUOROBENZYLAMINE 1,1-Dibenzylhydrazine (4-BROMOBENZYL)METHYLAMINE

(2-FLUORO-BENZYL)-HYDRAZINE (3-METHYL-4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID (4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETIC ACID 3-(2-FORMYLPHENYL)PROPANOIC ACID CHEMBRDG-BB 5937785

4-BROMO-BENZYL-HYDRAZINE 4-Bromo-2-fluorotoluene 4-ETHYL-2H-PHTHALAZIN-1-ONE

1of3

3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL) 3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid ICI-128436 ICI-plc MK-538 2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid Ponalrestat Statil STATIL [3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID Ponalrestat Ponalrestat (MK-538 ICI128436,ICI 128436,glucose,ALR,AKR1B1,Ponalrestat,Inhibitor,Aldose Reductase,conversion,inhibit,sorbitol,ICI-128436,orally,noncompetitive,ALR2,ALR1 Ponalrestat, 10 mM in DMSO Ponalrestat - Bio-X ? 72702-95-5 C17H12BrFN2O3 Inhibitors