Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>humanin

humanin

humanin Structure
humanin structure
CAS No.
330936-69-1
Chemical Name:
humanin
Synonyms
HUMANIN;HN;Humanin S14-G;Humanin, HN;Humanin (1);HUMANIN (HUMAN);Humanin(human) acetate;Protein humanin (human);MAPGSGCLLLLTSEIDLPVKRRA;MAPRGFSCLLLLTSEIDLPVKRRA
CBNumber:
CB6205843
Molecular Formula:
C119H204N34O32S2
Molecular Weight:
2687.27
MDL Number:
MFCD03787970
MOL File:
330936-69-1.mol
MSDS File:
SDS
Last updated:2024-07-02 08:55:13
Request For Quotation

humanin Properties

Density 1.43±0.1 g/cm3(Predicted)
storage temp. −20°C
form solid
color White to off-white
Sequence Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
InChIKey DPEUWKZJZIPZKE-YSUKGSMWNA-N

SAFETY

Risk and Safety Statements

WGK Germany  3

humanin price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J66525 Humanin, human 330936-69-1 5mg $481 2023-06-20 Buy
Cayman Chemical 24150 Humanin ≥95% 330936-69-1 500μg $149 2021-12-16 Buy
Cayman Chemical 24150 Humanin ≥95% 330936-69-1 1mg $268 2021-12-16 Buy
Biorbyt Ltd orb372420 Humanin > 95% 330936-69-1 1mg $552.5 2021-12-16 Buy
American Custom Chemicals Corporation PEP0000121 [D-SER14]-HUMANIN (HN) 95.00% 330936-69-1 0.5MG $823.52 2021-12-16 Buy
Product number Packaging Price Buy
J66525 5mg $481 Buy
24150 500μg $149 Buy
24150 1mg $268 Buy
orb372420 1mg $552.5 Buy
PEP0000121 0.5MG $823.52 Buy

humanin Chemical Properties,Uses,Production

General Description

Humanin (HN) is a natural short mitochondrial polypeptide with antiapoptotic and neuroprotective effects. Humanin protects cells against various diseases, including oxidative stress and cytotoxicity induced by various stimuli with broad-spectrum activity on the pancreas, brain, testis, and heart.

Biological Activity

Humanin (HN/MTRNR2) has also been cloned as a BAX partner that could suppress apoptosis caused by staurosporine, serum deprivation, or u.v. irradiation. Using co-immunoprecipitation experiments, humanin specifically bound to BAX, tBID, and BimEL (BCL2L11), but not other BCL2 family proteins such as BCL2 and BCL-B (BCL2L10). Furthermore, the anti-apoptotic effect of humanin was specific to BAX-dependent apoptosis, as apoptosis by a BAX-independent stimulus, such as the use of tumor necrosis factor, was not suppressed. Humanin also interacts with insulin-like growth factor-binding protein 3 (IGFBP3), where it can block IGFBP3-induced apoptosis in glial cell lines but not in neuronal cell lines or primary neurons[1].

Biochem/physiol Actions

Humanin is 24-amino acid mitochondria-associated peptide that is involved in numerous biological processes including apoptosis, cell survival, substrate metabolism, inflammatory response, and response to stressors such as oxidative stress, ischemia, and starvation. Humanin exhibits protective effects against cellular apoptosis. Apparently it inhibits BAX translocation to the mitochondrial outer membrane.

References

[1] Kelvin Yen. “The emerging role of the mitochondrial-derived peptide humanin in stress resistance.” Journal of molecular endocrinology 50 1 (2013): R11-9.

humanin Preparation Products And Raw materials

Raw materials

Preparation Products

humanin Suppliers

Global( 109)Suppliers
Supplier Tel Email Country ProdList Advantage
zhuzhou dingcheng meihei comestic co.,ltd
+8618873369619 dingchengbusiness8@163.com China 260 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823 admin@guyunchem.com China 616 58
Shanghai Affida new material science and technology center
+undefined15081010295 admin@oudaxin.com China 114 58
Dorne Chemical Technology co. LTD 		+86-86-13583358881 +8618560316533 Ethan@dornechem.com China 3145 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10977 58
Hebei Xinsheng New Material Technology Co., LTD. 		+86-16632316109 xinshengkeji@xsmaterial.com China 1090 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Hebei Anlijie Biotechnology Co., Ltd 		+8619031013551 ably@aljbio.com China 145 58
Shijiazhuang Saixin Technology Co., Ltd. 		+86-16632312509 +86-16632315022 saixinkeji@aliyun.com China 90 58
Hebei Weimiao Import and Export Trade Co., Ltd. 		+undefined19948166995 sale01@hbweimiao.com China 73 58
Supplier Advantage
zhuzhou dingcheng meihei comestic co.,ltd
58
Nantong Guangyuan Chemicl Co,Ltd
58
Shanghai Affida new material science and technology center
58
Dorne Chemical Technology co. LTD 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Hebei Xinsheng New Material Technology Co., LTD. 		58
Anhui Ruihan Technology Co., Ltd 		58
Hebei Anlijie Biotechnology Co., Ltd 		58
Shijiazhuang Saixin Technology Co., Ltd. 		58
Hebei Weimiao Import and Export Trade Co., Ltd. 		58

View Lastest Price from humanin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
HUMANIN TRIFLUOROACETATE pictures 2024-08-24 HUMANIN TRIFLUOROACETATE
330936-69-1
 US $1.00 / g 1g 99% 100kg Dorne Chemical Technology co. LTD
humanin pictures 2024-08-24 humanin
330936-69-1
 US $30.00 / Box 1Box 99.99% 10000000000 zhuzhou dingcheng meihei comestic co.,ltd
Humanin HN pictures 2024-08-21 Humanin HN
330936-69-1
 US $30.00-100.00 / g 10g 98% 2000kg hebei hongtan Biotechnology Co., Ltd
  • humanin pictures
  • humanin
    330936-69-1
  • US $30.00 / Box
  • 99.99%
  • zhuzhou dingcheng meihei comestic co.,ltd
  • Humanin HN pictures
  • Humanin HN
    330936-69-1
  • US $30.00-100.00 / g
  • 98%
  • hebei hongtan Biotechnology Co., Ltd

330936-69-1(humanin)Related Search:

ANSERINE Thymine Nesiritide acetate PNC27 peptide Elcatonin
Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide Pentapeptide-18 L-Lysyl-L-alpha-aspartyl-L-valyl-N5-(aminocarbonyl)-L-ornithine Rigin L-Carnosine
L-Leu-Leu-Leu GLY-PHE-SER [GLY14]-HUMANIN TRIFLUOROACETATE HUMANIN TRIFLUOROACETATE [125I]-HUMANIN (HUMAN)

1of3

MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA TRIFLUOROACETATE MAPRGFSCLLLLTSEIDLPVKRRA HNMET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA H-MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA-OH H-MAPRGFSCLLLLTSEIDLPVKRRA-OH HUMANIN (HUMAN) HUMANIN TRIFLUOROACETATE 1-24-Protein humanin (human) L-Alanine, L-methionyl-L-alanyl-L-prolyl-L-arginylglycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L- alpha-glutamyl-L-isoleucyl-L-alpha-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl- Protein (human clone 1 humanin sequence homolog) Protein humanin (human) T Lymphocyte activation-associated protein Pro86272 (human) Humanin, HN Humanin (1) MAPGSGCLLLLTSEIDLPVKRRA Drepanopeziza populorum (Desm.) Hö Leucostoma persoonii (Nitschke) Hö L-Alanine, L-methionyl-L-alanyl-L-prolyl-L-arginylglycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl- Humanin(human)trifluoroacetate Humanin(human) acetate HN HUMANIN Humanin S14-G 330936-69-1 C119H203N34O32S2 C119H204N34O32S2 Amino Acids and Peptides Biochemicals and Reagents BioChemical Other Alzheimer's Peptides Peptides Neurodegenerative Disease Peptides Peptide Alzheimers and Neurodegenerative Disease Research Neurobiology Neurodegenerative Disease Peptides Other Alzheimer Peptides OtherNeuropeptides