humanin
- CAS No.
- 330936-69-1
- Chemical Name:
- humanin
- Synonyms
- HUMANIN;HN;Humanin S14-G;Humanin, HN;Humanin (1);HUMANIN (HUMAN);Humanin(human) acetate;Protein humanin (human);MAPGSGCLLLLTSEIDLPVKRRA;MAPRGFSCLLLLTSEIDLPVKRRA
- CBNumber:
- CB6205843
- Molecular Formula:
- C119H204N34O32S2
- Molecular Weight:
- 2687.27
- MDL Number:
- MFCD03787970
- MOL File:
- 330936-69-1.mol
- MSDS File:
- SDS
humanin price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J66525 | Humanin, human | 330936-69-1 | 5mg | $481 | 2023-06-20 | Buy |
Cayman Chemical | 24150 | Humanin ≥95% | 330936-69-1 | 500μg | $149 | 2021-12-16 | Buy |
Cayman Chemical | 24150 | Humanin ≥95% | 330936-69-1 | 1mg | $268 | 2021-12-16 | Buy |
Biorbyt Ltd | orb372420 | Humanin > 95% | 330936-69-1 | 1mg | $552.5 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | PEP0000121 | [D-SER14]-HUMANIN (HN) 95.00% | 330936-69-1 | 0.5MG | $823.52 | 2021-12-16 | Buy |
humanin Chemical Properties,Uses,Production
General Description
Humanin (HN) is a natural short mitochondrial polypeptide with antiapoptotic and neuroprotective effects. Humanin protects cells against various diseases, including oxidative stress and cytotoxicity induced by various stimuli with broad-spectrum activity on the pancreas, brain, testis, and heart.
Biological Activity
Humanin (HN/MTRNR2) has also been cloned as a BAX partner that could suppress apoptosis caused by staurosporine, serum deprivation, or u.v. irradiation. Using co-immunoprecipitation experiments, humanin specifically bound to BAX, tBID, and BimEL (BCL2L11), but not other BCL2 family proteins such as BCL2 and BCL-B (BCL2L10). Furthermore, the anti-apoptotic effect of humanin was specific to BAX-dependent apoptosis, as apoptosis by a BAX-independent stimulus, such as the use of tumor necrosis factor, was not suppressed. Humanin also interacts with insulin-like growth factor-binding protein 3 (IGFBP3), where it can block IGFBP3-induced apoptosis in glial cell lines but not in neuronal cell lines or primary neurons[1].
Biochem/physiol Actions
Humanin is 24-amino acid mitochondria-associated peptide that is involved in numerous biological processes including apoptosis, cell survival, substrate metabolism, inflammatory response, and response to stressors such as oxidative stress, ischemia, and starvation. Humanin exhibits protective effects against cellular apoptosis. Apparently it inhibits BAX translocation to the mitochondrial outer membrane.
References
[1] Kelvin Yen. “The emerging role of the mitochondrial-derived peptide humanin in stress resistance.” Journal of molecular endocrinology 50 1 (2013): R11-9.
humanin Preparation Products And Raw materials
Raw materials
Preparation Products
humanin Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
zhuzhou dingcheng meihei comestic co.,ltd | +8618873369619 | dingchengbusiness8@163.com | China | 260 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 | admin@oudaxin.com | China | 114 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3145 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10977 | 58 |
Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1090 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 | ably@aljbio.com | China | 145 | 58 |
Shijiazhuang Saixin Technology Co., Ltd. | +86-16632312509 +86-16632315022 | saixinkeji@aliyun.com | China | 90 | 58 |
Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 | sale01@hbweimiao.com | China | 73 | 58 |
View Lastest Price from humanin manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-24 | HUMANIN TRIFLUOROACETATE
330936-69-1
|
US $1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD | |
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2024-08-24 | humanin
330936-69-1
|
US $30.00 / Box | 1Box | 99.99% | 10000000000 | zhuzhou dingcheng meihei comestic co.,ltd | |
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2024-08-21 | Humanin HN
330936-69-1
|
US $30.00-100.00 / g | 10g | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd |
-
- HUMANIN TRIFLUOROACETATE
330936-69-1
- US $1.00 / g
- 99%
- Dorne Chemical Technology co. LTD
-
- humanin
330936-69-1
- US $30.00 / Box
- 99.99%
- zhuzhou dingcheng meihei comestic co.,ltd
-
- Humanin HN
330936-69-1
- US $30.00-100.00 / g
- 98%
- hebei hongtan Biotechnology Co., Ltd