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humanin

humanin Suppliers list
Company Name: zhuzhou dingcheng meihei comestic co.,ltd
Tel: +8618873369619
Email: dingchengbusiness8@163.com
Products Intro: Product Name:humanin
CAS:330936-69-1
Purity:99.99% Package:1Box;30USD
Company Name: Nantong Guangyuan Chemicl Co,Ltd
Tel: +undefined17712220823
Email: admin@guyunchem.com
Products Intro: Product Name:Humanin
CAS:330936-69-1
Purity:99% Package:1mg;10.00;USD
Company Name: Shanghai Affida new material science and technology center
Tel: +undefined15081010295
Email: admin@oudaxin.com
Products Intro: Product Name:Humanin
CAS:330936-69-1
Purity:99 Package:1Box;0.00;USD|2Box;0.00;USD|5Box;0.00;USD
Company Name: Changsha MOL Changes Biotechnology Co., Ltd.
Tel: +8619375158599
Email: info@molchanges.com
Products Intro: Product Name:Humanin (human);Humanin
CAS:330936-69-1
Purity:99% Package:5mg;10mg;100mg;1g;10g;100g
Company Name: Dorne Chemical Technology co. LTD
Tel: +86-86-13583358881 +8618560316533
Email: Ethan@dornechem.com
Products Intro: Product Name:HUMANIN TRIFLUOROACETATE
CAS:330936-69-1
Purity:99% Package:1g;1.00;USD

humanin manufacturers

  • Humanin HN
  • Humanin HN pictures
  • $30.00 / 10g
  • 2024-12-24
  • CAS:330936-69-1
  • Min. Order: 10g
  • Purity: 98%
  • Supply Ability: 2000kg
  • Humanin
  • Humanin pictures
  • $0.00 / 1Box
  • 2024-12-20
  • CAS:330936-69-1
  • Min. Order: 1Box
  • Purity: 99
  • Supply Ability: 50000KG/month
humanin Basic information
Product Name:humanin
Synonyms:MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA;MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA TRIFLUOROACETATE;MAPRGFSCLLLLTSEIDLPVKRRA;HNMET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA;H-MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA-OH;H-MAPRGFSCLLLLTSEIDLPVKRRA-OH;HUMANIN (HUMAN);HUMANIN TRIFLUOROACETATE
CAS:330936-69-1
MF:C119H204N34O32S2
MW:2687.27
EINECS:200-048-4
Product Categories:Peptide;Alzheimers and Neurodegenerative Disease Research;Neurobiology;Neurodegenerative Disease Peptides;Other Alzheimer Peptides;OtherNeuropeptides
Mol File:330936-69-1.mol
humanin Structure
humanin Chemical Properties
density 1.43±0.1 g/cm3(Predicted)
storage temp. −20°C
form solid
color White to off-white
SequenceMet-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
InChIKeyDPEUWKZJZIPZKE-YSUKGSMWNA-N
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
humanin Usage And Synthesis
General Description Humanin (HN) is a natural short mitochondrial polypeptide with antiapoptotic and neuroprotective effects. Humanin protects cells against various diseases, including oxidative stress and cytotoxicity induced by various stimuli with broad-spectrum activity on the pancreas, brain, testis, and heart.
Biological Activity Humanin (HN/MTRNR2) has also been cloned as a BAX partner that could suppress apoptosis caused by staurosporine, serum deprivation, or u.v. irradiation. Using co-immunoprecipitation experiments, humanin specifically bound to BAX, tBID, and BimEL (BCL2L11), but not other BCL2 family proteins such as BCL2 and BCL-B (BCL2L10). Furthermore, the anti-apoptotic effect of humanin was specific to BAX-dependent apoptosis, as apoptosis by a BAX-independent stimulus, such as the use of tumor necrosis factor, was not suppressed. Humanin also interacts with insulin-like growth factor-binding protein 3 (IGFBP3), where it can block IGFBP3-induced apoptosis in glial cell lines but not in neuronal cell lines or primary neurons[1].
Biochem/physiol ActionsHumanin is 24-amino acid mitochondria-associated peptide that is involved in numerous biological processes including apoptosis, cell survival, substrate metabolism, inflammatory response, and response to stressors such as oxidative stress, ischemia, and starvation. Humanin exhibits protective effects against cellular apoptosis. Apparently it inhibits BAX translocation to the mitochondrial outer membrane.
References [1] Kelvin Yen. “The emerging role of the mitochondrial-derived peptide humanin in stress resistance.” Journal of molecular endocrinology 50 1 (2013): R11-9.
humanin Preparation Products And Raw materials
Tag:humanin(330936-69-1) Related Product Information
ANSERINE Thymine Nesiritide acetate PNC27 peptide Elcatonin Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide Pentapeptide-18 L-Lysyl-L-alpha-aspartyl-L-valyl-N5-(aminocarbonyl)-L-ornithine Rigin L-Carnosine L-Leu-Leu-Leu GLY-PHE-SER [GLY14]-HUMANIN TRIFLUOROACETATE HUMANIN TRIFLUOROACETATE [125I]-HUMANIN (HUMAN)