(+)-FANGCHINOLINE
- CAS No.
- 436-77-1
- Chemical Name:
- (+)-FANGCHINOLINE
- Synonyms
- Hanfangchin B（Fangchinoline）;(+)-limacine;Tetrandrine B;Hanfangichin B;FANGCHINO-LINE;Fangchinoline-RM;(+)-FANGCHINOLINE;FANGCHINOLINE (RG);7-o-demethyltetrandrine;12-O-MethylatherosperMoline
- CBNumber:
- CB6221346
- Molecular Formula:
- C37H40N2O6
- Molecular Weight:
- 608.72
- MDL Number:
- MFCD03427706
- MOL File:
- 436-77-1.mol
- MSDS File:
- SDS
| Melting point | 240～242℃ |
|---|---|
| Boiling point | 709.7±60.0 °C(Predicted) |
| Density | 1.204±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | Soluble in chloroform and methanol; |
| pka | 9.38±0.20(Predicted) |
| form | powder to crystal |
| color | White to Orange to Green |
| Water Solubility | slightly soluble in water |
| FDA UNII | 953592C3ZB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| HS Code | 2939.79.0000 | |||||||||
| NFPA 704 |
|
(+)-FANGCHINOLINE price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F1173 | Fangchinoline | 436-77-1 | 20MG | $75 | 2024-03-01 | Buy |
| TCI Chemical | F1173 | Fangchinoline | 436-77-1 | 100MG | $226 | 2024-03-01 | Buy |
| Cayman Chemical | 29243 | Fangchinoline | 436-77-1 | 5mg | $60 | 2024-03-01 | Buy |
| Cayman Chemical | 29243 | Fangchinoline | 436-77-1 | 10mg | $98 | 2024-03-01 | Buy |
| Cayman Chemical | 29243 | Fangchinoline | 436-77-1 | 50mg | $315 | 2024-03-01 | Buy |
(+)-FANGCHINOLINE Chemical Properties,Uses,Production
Description
Fangchinoline is an alkaloid that has been found in S. tetrandrae and has diverse biological activities, including anti-inflammatory, neuroprotective, and anticancer properties. It inhibits the activity of sheep COX and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells with IC50 values of 129 and 3.7 μM, respectively. Fangchinoline (1 and 10 μM) reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons. It decreases proliferation of PC3 human prostate cancer cells by 63 and 86% when used at concentrations of 20 and 30 μM, respectively. Fangchinoline reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 5 mg/kg per day for 12 days.
Description
A bisbenzylisoquino!ine alkaloid obtained from Limacia cuspidata (Miers.) Hook. f. et Thorn., the base crystallizes from Me2CO in the form of long, colourless needles. It is strongly laevorotatory with [α]D - 2120 (CHCI3) and has been shown to be the optical antipode of fanchinoline (q.v.).
Uses
(+)-Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.
Definition
ChEBI: A bisbenzylisoquinoline alkaloid that is (1beta)- berbaman which has been substituted by methyl groups at the 2 and 2' positions, by methoxy groups at the 6, 6', and 12 positions, and by a hydroxy group at position 7. Isolated from S ephania tetrandra, it has been found to possess neuroprotective and anti-tumour activity.
References
Tomita, Furukawa., Tetrahedron Lett., 4293 (1966)
(+)-FANGCHINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12840 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18154 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18779 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
View Lastest Price from (+)-FANGCHINOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Fangchinoline
436-77-1
|
US $43.00-97.00 / mg | 99.98% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-04 | (+)-FANGCHINOLINE
436-77-1
|
US $30.00-10.00 / KG | 50KG | 99% | 500000kg | Hebei Weibang Biotechnology Co., Ltd | |
 |
2023-10-16 | (+)-FANGCHINOLINE
436-77-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- Fangchinoline
436-77-1
- US $43.00-97.00 / mg
- 99.98%
- TargetMol Chemicals Inc.
-
- (+)-FANGCHINOLINE
436-77-1
- US $30.00-10.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- (+)-FANGCHINOLINE
436-77-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd