BIIB-021
- CAS No.
- 848695-25-0
- Chemical Name:
- BIIB-021
- Synonyms
- CS-479;CNF2024;BIIB-021;CNF-2024EC102;BIIB021/CNF2024;BIIB 021, ≥98%;BIIB021 BIIB-021;BIIB-021 USP/EP/BP;CNF 2024 - BIIB 021;BIIB021(CNF2024)BIIB021
- CBNumber:
- CB62516264
- Molecular Formula:
- C14H15ClN6O
- Molecular Weight:
- 318.76
- MDL Number:
- MFCD15528939
- MOL File:
- 848695-25-0.mol
- MSDS File:
- SDS
| Melting point | 192-193℃ |
|---|---|
| Boiling point | 588.5±60.0 °C(Predicted) |
| Density | 1.50 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (>25 mg/ml) |
| form | solid |
| pka | 6.07±0.40(Predicted) |
| color | White |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha. |
| FDA UNII | 851B9FQ7Q0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| HS Code | 2921490090 | |||||||||
| NFPA 704 |
|
BIIB-021 price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18269 | BIIB021 ≥98% | 848695-25-0 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 18269 | BIIB021 ≥98% | 848695-25-0 | 5mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 18269 | BIIB021 ≥98% | 848695-25-0 | 10mg | $88 | 2024-03-01 | Buy |
| Cayman Chemical | 18269 | BIIB021 ≥98% | 848695-25-0 | 25mg | $156 | 2024-03-01 | Buy |
| Tocris | 4608 | BIIB021 ≥98%(HPLC) | 848695-25-0 | 10 | $219 | 2021-12-16 | Buy |
BIIB-021 Chemical Properties,Uses,Production
Description
BIIB021 is a potent HSP90 inhibitor (IC50 = 30 nM HER-2 degradation).1 It inhibited the proliferation of MCF7 and BT474 breast cancer cell lines (IC50 = 100 nM for each).? BIIB021 has shown efficacy as a therapeutic in multiple cancer models.2-5
Uses
BIIB 021 an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Studies show that BIIB 021 adminisitration led to degradation of Hsp90 client proteins measured in tumor tissue and resulted in the inhibition of tumor growth in several human tumor xenograft models.
Definition
ChEBI: A member of the class of 2-aminopurines that is 2-aminopurine which is substituted by a chlorine at position 6 and by a (4-methoxy-3,5-dimethylpyridin-2-yl)methyl group at position 9.
References
Kasibhatla et al. (2007), Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity; J. Med. Chem. 50 2767 Lundgren et al. (2009), BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90; Mol. Cancer Ther. 8 921 Boll et al. (2009), Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin’s lymphoma cells for natural killer cell-mediated cytotoxicity; Clin. Cancer Res. 15 5108 Zhang et al. (2010), BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance; Int. J. Cancer 126 1226 Wang et al. (2014), BIIB021, a novel Hsp90 inhibitor, sensitizes esophageal squamous cell carcinoma to radiation; Biochem. Biophys. Res. Commun. 452 945
BIIB-021 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22883 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9237 | 58 |
