(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
![(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Structure](CAS/GIF/438190-29-5.gif)
- CAS No.
- 438190-29-5
- Chemical Name:
- (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
- Synonyms
- SMI-4a;CS-2669;CS-1477;SMI-4a（b）;(Z)-SMI-4a;TCS PIM-1 4a;SMI-4a, >97%;SMI-4A; SMI4A;TCS PIM-1 4a, >=98%;SMI-4a TCS PIM-1 4a
- CBNumber:
- CB62518905
- Molecular Formula:
- C11H6F3NO2S
- Molecular Weight:
- 273.23
- MDL Number:
- MFCD01152003
- MOL File:
- 438190-29-5.mol
- MSDS File:
- SDS
| Density | 1.530±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Desiccate at +4°C |
| solubility | DMSO: >10mg/mL |
| form | powder |
| pka | 7.38±0.20(Predicted) |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0323 | SMI-4a ≥98% (HPLC) | 438190-29-5 | 10mg | $118 | 2022-05-15 | Buy |
| Cayman Chemical | 11029 | SMI-4a ≥98% | 438190-29-5 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 11029 | SMI-4a ≥98% | 438190-29-5 | 5mg | $64 | 2024-03-01 | Buy |
| Cayman Chemical | 11029 | SMI-4a ≥98% | 438190-29-5 | 10mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 11029 | SMI-4a ≥98% | 438190-29-5 | 50mg | $384 | 2024-03-01 | Buy |
(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Chemical Properties,Uses,Production
Description
SMI-4a (438190-29-5) is a selective, ATP-competitive inhibitor of the Pim protein kinases (IC50 = 24 and 100 nM for Pim-1 and Pim-2 respectively). Selective over a panel of ~50 other kinases.1?Induces cell cycle arrest in leukemia and prostate cancer cells.2?Blocks the growth of a wide range of myeloid and lymphoid cell lines with precursor T-cell lymphoblastic leukemia/lymphoma (pre-T-LBL/T-ALL) being highly sensitive.3?SMI-4a is a useful tool for exploring the involvement of Pim in cellular signaling.4?Cell permeable.
Uses
SMI-4a is an aldose reductase inhibitor as well as a COX-2 inhibitor, a potential agent in the inhibition and treatment of cancer and cancer cell lines.
References
1) Xia et al. (2009), Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases; J. Med. Chem., 52 74 2) Beharry et al. (2009), Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells; Mol. Cancer Ther., 8 1473 3) Lin et al. (2010), A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma; Blood, 115 824 4) Zhang et al. (2009), PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells; Cancer Biol. Ther., 8 846
(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29882 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22883 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-17 | (Z)-SMI-4a
438190-29-5
|
US $228.00-66.00 / mg | 99.44% | 10g | TargetMol Chemicals Inc. | ||
![(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione pictures](https://img.chemicalbook.com/ProductImageEN/2019-9/Small/d330a174-c4e0-491b-b584-ffde058fc907.png) |
2019-09-04 | (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
438190-29-5
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- (Z)-SMI-4a
438190-29-5
- US $228.00-66.00 / mg
- 99.44%
- TargetMol Chemicals Inc.
-
- (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
438190-29-5
- US $5.00 / KG
- 99%
- Career Henan Chemical Co