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PF-04457845

PF-04457845 Structure
PF-04457845 structure
CAS No.
1020315-31-4
Chemical Name:
PF-04457845
Synonyms
CS-1549;PF-04457845;PF-04457845;PF04457845;PF-04457845 >=98% (HPLC);Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide;1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
CBNumber:
CB62522724
Molecular Formula:
C23H20F3N5O2
Molecular Weight:
455.43
MDL Number:
MFCD18782721
MOL File:
1020315-31-4.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22
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PF-04457845 Properties

Boiling point 687.0±55.0 °C(Predicted)
Density 1.389±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
pka 12.72±0.20(Predicted)
form powder
color white to beige
FDA UNII H4C81M8YYW

SAFETY

Risk and Safety Statements

WGK Germany  3

PF-04457845 price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0184 PF-04457845 ≥98% (HPLC) 1020315-31-4 5MG $108 2023-06-20 Buy
Sigma-Aldrich PZ0184 PF-04457845 ≥98% (HPLC) 1020315-31-4 25MG $438 2023-06-20 Buy
Cayman Chemical 19306 PF-04457845 ≥98% 1020315-31-4 5mg $68 2024-03-01 Buy
Cayman Chemical 19306 PF-04457845 ≥98% 1020315-31-4 10mg $121 2024-03-01 Buy
Cayman Chemical 19306 PF-04457845 ≥98% 1020315-31-4 25mg $286 2024-03-01 Buy
Product number Packaging Price Buy
PZ0184 5MG $108 Buy
PZ0184 25MG $438 Buy
19306 5mg $68 Buy
19306 10mg $121 Buy
19306 25mg $286 Buy

PF-04457845 Chemical Properties,Uses,Production

Biochem/physiol Actions

PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.

storage

Store at +4°C

PF-04457845 synthesis

1020327-61-0
1020325-53-4
1020315-31-4
Synthesis of PF-04457845 from CarbaMic acid, N-3-pyridazinyl-, phenyl ester and Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1)

PF-04457845 Preparation Products And Raw materials

Raw materials

Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1) Phosphonic acid, P-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methyl]-, diethyl ester CarbaMic acid, N-3-pyridazinyl-, phenyl ester BenzeneMethanol, 3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]- Pyridine, 2-[3-(chloroMethyl)phenoxy]-5-(trifluoroMethyl)-
3-Hydroxybenzyl alcohol 2-Chloro-5-trifluoromethylpyridine

1of2

Preparation Products

PF-04457845 Suppliers

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33338 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
LEAPCHEM CO., LTD. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58

View Lastest Price from PF-04457845 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-04457845 pictures 2024-11-19 PF-04457845
1020315-31-4
 US $30.00-81.00 / mg 100% 10g TargetMol Chemicals Inc.
  • PF-04457845 pictures
  • PF-04457845
    1020315-31-4
  • US $30.00-81.00 / mg
  • 100%
  • TargetMol Chemicals Inc.
N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide PF-04457845 N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide PF-04457845;PF04457845 1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]- N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide CS-1549 PF-04457845 >=98% (HPLC) Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor 1020315-31-4 C23H20F3N5O2