CAY10499
- CAS No.
- 359714-55-9
- Chemical Name:
- CAY10499
- Synonyms
- CAY10499;CAY10499 Exclusive;QTENHWTVRQKWRI-UHFFFAOYSA-N;Inhibitor,inhibit,MAGLIN5,MAGL IN 5,FAAH,Fatty acid amide hydrolase,Monoacylglycerol lipase,MAGL;Carbamic acid, N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-, phenylmethyl ester
- CBNumber:
- CB62590413
- Molecular Formula:
- C18H17N3O5
- Molecular Weight:
- 355.34
- MDL Number:
- MFCD12912259
- MOL File:
- 359714-55-9.mol
CAY10499 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10007875 | CAY10499 ≥98% | 359714-55-9 | 1mg | $16 | 2024-03-01 | Buy |
| Cayman Chemical | 10007875 | CAY10499 ≥98% | 359714-55-9 | 5mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 10007875 | CAY10499 ≥98% | 359714-55-9 | 10mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 10007875 | CAY10499 ≥98% | 359714-55-9 | 25mg | $235 | 2024-03-01 | Buy |
| ApexBio Technology | B7841 | CAY10499 | 359714-55-9 | 10mg | $154 | 2021-12-16 | Buy |
CAY10499 Chemical Properties,Uses,Production
Description
CAY10499 is a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). It also inhibits ATGL, DAGLa, ABHD6, and CES1 by 95, 60, 90, and 95%, respectively, when used at a concentration of 5 mM. CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 μM, respectively). In vivo, CAY10499 reduces FRUC diet- and AIN-93M diet-induced increases in cytosolic lipase activity in rats.
Definition
ChEBI: CAY10499 is a carbamate ester.
References
[1] muccioli g g, labar g, lambert d m. cay10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious mgl assay[j]. chembiochem, 2008, 9(16): 2704-2710.
[2] ben ali y, muller g, petry s, et al. kinetic characterization and specific inhibition of hormone sensitive lipase[c]//chemistry and physics of lipids. elsevier house, brookvale plaza, east park shannon, co, clare, 00000, ireland: elsevier ireland ltd, 2005, 136(2): 155-155.
[3] kraemer f b, shen w j. hormone-sensitive lipase control of intracellular tri-(di-) acylglycerol and cholesteryl ester hydrolysis[j]. journal of lipid research, 2002, 43(10): 1585-1594.
CAY10499 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10499 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 384 | 55 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3058 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5587 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |