DMAPT
- CAS No.
- 870677-05-7
- Chemical Name:
- DMAPT
- Synonyms
- DMAPT;Dimethylamino Parthenolide;UJNSFDHVIBGEJZ-KVUCBBCISA-N;NF-κB,Inhibitor,Nuclear factor-κB,inhibit,DMAPT,Nuclear factor-kappaB;(1S,2R,4R,7~{Z},11S,12S)-12-[(dimethylamino)methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one;Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-, (1aR,4E,7aS,8S,10aS,10bR)-
- CBNumber:
- CB62627768
- Molecular Formula:
- C17H27NO3
- Molecular Weight:
- 293.4
- MDL Number:
- MFCD32062837
- MOL File:
- 870677-05-7.mol
| storage temp. | -20°C |
|---|---|
| solubility | Soluble in DMSO, Ethyl acetate, or Ethanol. |
| form | solid |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol, or ethyl acetate may be stored at -20° for up to 1 month. |
| FDA UNII | U41S5CG0SG |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P302+P352-P305+P351+P338-P362+P364 |
| HS Code | 2932209090 |
DMAPT price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20436 | Dimethylamino Parthenolide ≥99% | 870677-05-7 | 10mg | $115 | 2022-04-27 | Buy |
| Cayman Chemical | 20436 | Dimethylamino Parthenolide ≥99% | 870677-05-7 | 25mg | $242 | 2022-04-27 | Buy |
| Biosynth Carbosynth | BD162719 | Dimethylamino parthenolide | 870677-05-7 | 50mg | $250 | 2021-12-16 | Buy |
| AK Scientific | 7347EJ | Dmapt | 870677-05-7 | 25mg | $401 | 2021-12-16 | Buy |
| ChemScene | CS-0006176 | DMAPT ≥98.0% | 870677-05-7 | 10mg | $150 | 2021-12-16 | Buy |
DMAPT Chemical Properties,Uses,Production
Description
DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFκB and stimulates the formation of reactive oxygen species which induced the activation of JNK.1 In non-small cell lung cancers DMAPT inhibits NFκB and DNA double-strand break repair.2
Uses
DMAPT is a parthenolide derivative that functions as an antileukemic and cytotoxic agents.
References
1) Shanmugam?et al. (2011),?A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NFκB and generating reactive oxygen species; Int. J. Cancer,?128?2481 2) Estrabrook?et al. (2011),?Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays; Free Radic. Biol. Med.,?51?2249
DMAPT Preparation Products And Raw materials
Raw materials
Preparation Products
DMAPT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 029-81118914 18066712840 | 1027@dideu.com | China | 10011 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11442 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10000 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Carbosynth | -- | sales@carbosynth.com | United Kingdom | 6018 | 58 |