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SIRT2 Inhibitor, Inactive Control, AGK7

CAS No.
304896-21-7
Chemical Name:
SIRT2 Inhibitor, Inactive Control, AGK7
Synonyms
AGK7;SIRT2 Inhibitor, Inactive Control, AGK7;2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide;2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl-;Parkinson's disease,sirtuin 2,morphology,SIRT2 Inhibitor,Inactive Control,AGK 7,Drosophila,inhibit,toxicity,Inhibitor,AGK7,alpha-synuclein,dopaminergic cell death,AGK-7,Sirtuin
CBNumber:
CB62645098
Molecular Formula:
C23H13Cl2N3O2
Molecular Weight:
434.27
MDL Number:
MOL File:
304896-21-7.mol
Last updated:2023-09-04 16:42:00

SIRT2 Inhibitor, Inactive Control, AGK7 Properties

storage temp. +2C to +8C
solubility ≤0.5mg/ml in DMSO;0.2mg/ml in dimethyl formamide
form Yellow solid

SIRT2 Inhibitor, Inactive Control, AGK7 price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 566326 SIRT2 Inhibitor, Inactive Control, AGK7 - CAS 304896-21-7 - Calbiochem 304896-21-7 5mg $238 2023-01-07 Buy
Cayman Chemical 16152 AGK7 ≥95% 304896-21-7 1mg $61 2024-03-01 Buy
Cayman Chemical 16152 AGK7 ≥95% 304896-21-7 5mg $118 2024-03-01 Buy
Cayman Chemical 16152 AGK7 ≥95% 304896-21-7 10mg $207 2024-03-01 Buy
Cayman Chemical 16152 AGK7 ≥95% 304896-21-7 25mg $437 2024-03-01 Buy
Product number Packaging Price Buy
566326 5mg $238 Buy
16152 1mg $61 Buy
16152 5mg $118 Buy
16152 10mg $207 Buy
16152 25mg $437 Buy

SIRT2 Inhibitor, Inactive Control, AGK7 Chemical Properties,Uses,Production

Description

AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. AGK7 is an inactive control to be used in experiments with AGK2. It differs from AGK2, structurally, only in the position of nitrogen in the quinoline group. AGK7 has IC50 values greater than 50 μM on SIRT1 and SIRT2 and greater than 5 μM on SIRT3.

References

[1]. outeiro tf, kontopoulos e, altmann sm, et al. sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of parkinson's disease. science. 2007 jul 27;317(5837):516-9.
[2]. cole pa. chemical probes for histone-modifying enzymes. nat chem biol. 2008 oct;4(10):590-7.

SIRT2 Inhibitor, Inactive Control, AGK7 Preparation Products And Raw materials

Raw materials

Preparation Products

SIRT2 Inhibitor, Inactive Control, AGK7 Suppliers

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SIRT2 Inhibitor, Inactive Control, AGK7 Spectrum

SIRT2 Inhibitor, Inactive Control, AGK7 AGK7 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide 2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl- Parkinson's disease,sirtuin 2,morphology,SIRT2 Inhibitor,Inactive Control,AGK 7,Drosophila,inhibit,toxicity,Inhibitor,AGK7,alpha-synuclein,dopaminergic cell death,AGK-7,Sirtuin 304896-21-7