5-Ethynyl-2'-deoxycytidine
- CAS No.
- 69075-47-4
- Chemical Name:
- 5-Ethynyl-2'-deoxycytidine
- Synonyms
- 5-Ethynyl-2'-dC;-Ethynyl-2’5-Ethynyl-2'-deoxycytidine;5-Ethynyl-2'-deoxycytidine;2'-Deoxy-5-ethynylcytidine;5'-Ethynyl-2'-deoxycytidine;5-Ethynyl-2'-deoxycytidine>Cytidine, 2'-deoxy-5-ethynyl-;5-Ethynyl-2′-deoxycytidine, (EdC);5-Ethynyl-2'-deoxycytidine 69075-47-4
- CBNumber:
- CB62682226
- Molecular Formula:
- C11H13N3O4
- Molecular Weight:
- 251.24
- MDL Number:
- MFCD22417249
- MOL File:
- 69075-47-4.mol
- MSDS File:
- SDS
Melting point | 191 °C (decomp)(Solv: dichloromethane (75-09-2); methanol (67-56-1)) |
---|---|
Boiling point | 475.7±55.0 °C(Predicted) |
Density | 1.54±0.1 g/cm3(Predicted) |
storage temp. | Store at 2-8°C, protect from light, stored under nitrogen |
solubility | DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml |
pka | 14.03±0.60(Predicted) |
form | powder to crystal |
color | White to Light yellow to Light orange |
λmax | 292nm(H2O)(lit.) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
WGK Germany | 3 |
HS Code | 2934.99.4400 |
5-Ethynyl-2'-deoxycytidine price More Price(20)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | T511307 | 5-Ethynyl-2′-deoxycytidine, (EdC) AldrichCPR | 69075-47-4 | 5mg | $180 | 2024-03-01 | Buy |
TCI Chemical | E1093 | 5-Ethynyl-2'-deoxycytidine >98.0%(N) | 69075-47-4 | 50mg | $203 | 2021-12-16 | Buy |
TCI Chemical | E1093 | 5-Ethynyl-2'-deoxycytidine >98.0%(N) | 69075-47-4 | 200mg | $712 | 2024-03-01 | Buy |
Cayman Chemical | 11581 | 5'-Ethynyl-2'-deoxycytidine ≥98% | 69075-47-4 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 11581 | 5'-Ethynyl-2'-deoxycytidine ≥98% | 69075-47-4 | 5mg | $116 | 2024-03-01 | Buy |
5-Ethynyl-2'-deoxycytidine Chemical Properties,Uses,Production
Description
5''-Ethynyl-2''-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID50 = 0.2 μg/mL). It also reduces virus-induced cytopathogenicity of HSV-1, HSV-2, and vaccinia virus strains in PRK cells (MICs = 0.2-0.4, 1-2, and 5 μg/ml, respectively). EdC is an inhibitor of thymidylate synthetase, selectively reducing DNA incorporation of [1'',2''-3H]deoxyuridine over [CH3-3H]deoxythymidine in PRK cells (ID50s = 3 and 120 μg/ml, respectively). It inhibits thymidine synthetase in and reduces proliferation of L1210 cells, an effect which is reversed by addition of deoxythymidine (ID50s = 4.4 and 1,000 μg/ml, respectively). EdC has been used to monitor DNA synthesis and cellular replication via click chemistry conjugation of the ethynyl group to an azido group of various fluorochromes.
Uses
5-Ethynyl-2’-deoxycytidine is an lower toxicity analog of 2’-deoxycytidine, a metabolic labeling probe for DNA synthesis. 5-Ethynyl-2’-deoxycytidine is most commonly used when thymidine analogs is undesirable.
Uses
A relatively nontoxic 2′-deoxycytidine analog for metabolic labeling of newly synthesized DNA in vivo. Especially suitable if the use of thymidine analogs is undesirable.
5-Ethynyl-2'-deoxycytidine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9602 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5988 | 58 |
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9980 | 58 |
Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 | sales1@nuowei-chem.com | China | 1640 | 58 |
Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
View Lastest Price from 5-Ethynyl-2'-deoxycytidine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-22 | 5-Ethynyl-2'-deoxycytidine
69075-47-4
|
US $0.00-0.00 / g | 10g | 98%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2022-09-27 | 5-Ethynyl-2'-deoxycytidine
69075-47-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
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2020-03-05 | 5-Ethynyl-2'-deoxycytidine
69075-47-4
|
US $1.00 / KG | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- 5-Ethynyl-2'-deoxycytidine
69075-47-4
- US $0.00-0.00 / g
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 5-Ethynyl-2'-deoxycytidine
69075-47-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-Ethynyl-2'-deoxycytidine
69075-47-4
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co