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ChemicalBook >> CAS DataBase List >> 5-Ethynyl-2'-deoxycytidine

5-Ethynyl-2'-deoxycytidine

5-Ethynyl-2'-deoxycytidine price.
  • $32 - $875
  • Product name: 5-Ethynyl-2'-deoxycytidine
  • CAS: 69075-47-4
  • MF: C11H13N3O4
  • MW: 251.24
  • EINECS:-0
  • MDL Number:MFCD22417249
  • Synonyms:5-Ethynyl-2′-deoxycytidine, (EdC);Cytidine, 2'-deoxy-5-ethynyl-;2'-Deoxy-5-ethynylcytidine;5-Ethynyl-2'-deoxycytidine, (EdC) AldrichCPR;5-Ethynyl-2'-deoxycytidine;5-Ethynyl-2'-dC;4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;-Ethynyl-2&rsquo
18 prices
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Brand
  • AK Scientific
  • Ambeed
  • Biosynth Carbosynth
  • Cayman Chemical
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
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  • 1g
  • ManufacturerAK Scientific
  • Product number6771AL
  • Product description5-Ethynyl-2'-deoxycytidine
  • Packaging50mg
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA311059
  • Product description4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 98%
  • Packaging50mg
  • Price$78
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA311059
  • Product description4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 98%
  • Packaging100mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA311059
  • Product description4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 98%
  • Packaging250mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA311059
  • Product description4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 98%
  • Packaging1g
  • Price$426
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberND161709
  • Product description2'-Deoxy-5-ethynylcytidine
  • Packaging500mg
  • Price$875
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberND161709
  • Product description2'-Deoxy-5-ethynylcytidine
  • Packaging250mg
  • Price$500
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberND161709
  • Product description2'-Deoxy-5-ethynylcytidine
  • Packaging100mg
  • Price$350
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberND161709
  • Product description2'-Deoxy-5-ethynylcytidine
  • Packaging50mg
  • Price$150
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberND161709
  • Product description2'-Deoxy-5-ethynylcytidine
  • Packaging25mg
  • Price$95
  • Updated2021-12-16
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  • ManufacturerCayman Chemical
  • Product number11581
  • Product description5'-Ethynyl-2'-deoxycytidine ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11581
  • Product description5'-Ethynyl-2'-deoxycytidine ≥98%
  • Packaging5mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11581
  • Product description5'-Ethynyl-2'-deoxycytidine ≥98%
  • Packaging10mg
  • Price$214
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11581
  • Product description5'-Ethynyl-2'-deoxycytidine ≥98%
  • Packaging25mg
  • Price$456
  • Updated2024-03-01
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  • ManufacturerSigma-Aldrich
  • Product numberT511307
  • Product description5-Ethynyl-2′-deoxycytidine, (EdC) AldrichCPR
  • Packaging5mg
  • Price$180
  • Updated2024-03-01
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  • ManufacturerTCI Chemical
  • Product numberE1093
  • Product description5-Ethynyl-2'-deoxycytidine >98.0%(N)
  • Packaging50mg
  • Price$203
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6771AL 5-Ethynyl-2'-deoxycytidine 50mg $252 2021-12-16 Buy
Ambeed A311059 4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 98% 50mg $78 2021-12-16 Buy
Ambeed A311059 4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 98% 100mg $112 2021-12-16 Buy
Ambeed A311059 4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 98% 250mg $176 2021-12-16 Buy
Ambeed A311059 4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 98% 1g $426 2021-12-16 Buy
Biosynth Carbosynth ND161709 2'-Deoxy-5-ethynylcytidine 500mg $875 2021-12-16 Buy
Biosynth Carbosynth ND161709 2'-Deoxy-5-ethynylcytidine 250mg $500 2021-12-16 Buy
Biosynth Carbosynth ND161709 2'-Deoxy-5-ethynylcytidine 100mg $350 2021-12-16 Buy
Biosynth Carbosynth ND161709 2'-Deoxy-5-ethynylcytidine 50mg $150 2021-12-16 Buy
Biosynth Carbosynth ND161709 2'-Deoxy-5-ethynylcytidine 25mg $95 2021-12-16 Buy
Cayman Chemical 11581 5'-Ethynyl-2'-deoxycytidine ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 11581 5'-Ethynyl-2'-deoxycytidine ≥98% 5mg $116 2024-03-01 Buy
Cayman Chemical 11581 5'-Ethynyl-2'-deoxycytidine ≥98% 10mg $214 2024-03-01 Buy
Cayman Chemical 11581 5'-Ethynyl-2'-deoxycytidine ≥98% 25mg $456 2024-03-01 Buy
Sigma-Aldrich T511307 5-Ethynyl-2′-deoxycytidine, (EdC) AldrichCPR 5mg $180 2024-03-01 Buy
TCI Chemical E1093 5-Ethynyl-2'-deoxycytidine >98.0%(N) 50mg $203 2021-12-16 Buy

Properties

Melting point :191 °C (decomp)(Solv: dichloromethane (75-09-2); methanol (67-56-1))
Boiling point :475.7±55.0 °C(Predicted)
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :Store at 2-8°C, protect from light, stored under nitrogen
solubility :DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
pka :14.03±0.60(Predicted)
form :powder to crystal
color :White to Light yellow to Light orange
λmax :292nm(H2O)(lit.)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

5''-Ethynyl-2''-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID50 = 0.2 μg/mL). It also reduces virus-induced cytopathogenicity of HSV-1, HSV-2, and vaccinia virus strains in PRK cells (MICs = 0.2-0.4, 1-2, and 5 μg/ml, respectively). EdC is an inhibitor of thymidylate synthetase, selectively reducing DNA incorporation of [1'',2''-3H]deoxyuridine over [CH3-3H]deoxythymidine in PRK cells (ID50s = 3 and 120 μg/ml, respectively). It inhibits thymidine synthetase in and reduces proliferation of L1210 cells, an effect which is reversed by addition of deoxythymidine (ID50s = 4.4 and 1,000 μg/ml, respectively). EdC has been used to monitor DNA synthesis and cellular replication via click chemistry conjugation of the ethynyl group to an azido group of various fluorochromes.