8-OXO-2'-DEOXYGUANOSINE
- CAS No.
- 88847-89-6
- Chemical Name:
- 8-OXO-2'-DEOXYGUANOSINE
- Synonyms
- 8-hydroxydeoxyguanosine;8-Hydroxy-dG;-deoxyguanosine;8-Hydroxy-2'-dG;8-Oxodeoxyguanosine;2-Amino-9-((2R,4S,5R);-3H-purine-6,8(7H,9H);2'-Deoxy-8-oxoguanosine;8-oxo-2'-deoxyGuanosine;2’-Deoxy-8-oxoguanosine
- CBNumber:
- CB6269667
- Molecular Formula:
- C10H13N5O5
- Molecular Weight:
- 283.24
- MDL Number:
- MFCD00210311
- MOL File:
- 88847-89-6.mol
- MSDS File:
- SDS
| Melting point | 217-220°C |
|---|---|
| Density | 2.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 10 mg/ml). |
| pka | 7.86±0.20(Predicted) |
| form | White to off-white solid. |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| FDA UNII | 4RGB38T3IB |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | MF8782675 |
| HS Code | 29349990 |
8-OXO-2'-DEOXYGUANOSINE price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H5653 | 8-Hydroxy-2′-deoxyguanosine ≥98% (TLC) | 88847-89-6 | 1mg | $90.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | H5653 | 8-Hydroxy-2′-deoxyguanosine ≥98% (TLC) | 88847-89-6 | 5mg | $312 | 2024-03-01 | Buy |
| Cayman Chemical | 89320 | 8-Hydroxy-2'-deoxyguanosine ≥98% | 88847-89-6 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 89320 | 8-Hydroxy-2'-deoxyguanosine ≥98% | 88847-89-6 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 89320 | 8-Hydroxy-2'-deoxyguanosine ≥98% | 88847-89-6 | 10mg | $363 | 2024-03-01 | Buy |
8-OXO-2'-DEOXYGUANOSINE Chemical Properties,Uses,Production
Description
8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1?It is a critical biomarker for oxidative stress and carcinogenesis.2,3
Chemical Properties
White Crystalline Solid
Uses
8-Hydroxy-2′-deoxyguanosine has been used:
- as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
- as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
- as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential?antioxidant?activity of green coffee bean extract (GCBE) in vivo
- as a standard for LC/MS/MS analysis
Uses
A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.
Definition
ChEBI: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.
Biochem/physiol Actions
A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis
References
1) Beckman?et al. (1997),?Oxidative decay of DNA; J. Biol. Chem.,?272?19636 2) Andreoli?et al. (2010),?Quantitative determination of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile for healthy volunteers; Biomarkers,?15?221 3) Manini?et al. (2009),?Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers; Toxicol. Lett.,?190?41
8-OXO-2'-DEOXYGUANOSINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19825 | 58 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22854 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9985 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1249 | 58 |
View Lastest Price from 8-OXO-2'-DEOXYGUANOSINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 8-OXO-2'-DEOXYGUANOSINE
88847-89-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2024-11-19 | 8-Hydroxy-2'-deoxyguanosine
88847-89-6
|
US $81.00-167.00 / mg | 97.13% | 10g | TargetMol Chemicals Inc. |
-
- 8-OXO-2'-DEOXYGUANOSINE
88847-89-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 8-Hydroxy-2'-deoxyguanosine
88847-89-6
- US $81.00-167.00 / mg
- 97.13%
- TargetMol Chemicals Inc.
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