Proflavine hemisulfate
- CAS No.
- 1811-28-5
- Chemical Name:
- Proflavine hemisulfate
- Synonyms
- PROFLAVINE HEMISULPHATE;PROFLAVINE HEMISULFATE SALT;3,6-DIAMINOACRIDINIUM MONOHYDROGEN SULFATE;PROFLAVINE SULFATE;PROFLAVINE HEMISULFATE;Proflavin hemisulphate;PROFLAVINE HEMISULFATE;bis(acridine-3,6-diamine);3,6-DIAMINOACRIDINE SULFATE;2 8-DIAMINOACRIDINE SULFATE
- CBNumber:
- CB6285832
- Molecular Formula:
- C13H13N3O4S
- Molecular Weight:
- 307.32
- MDL Number:
- MFCD00013150
- MOL File:
- 1811-28-5.mol
- MSDS File:
- SDS
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
|---|---|
| solubility | DMSO (Slightly, Heated), Water (Slightly, Heated) |
| form | powder |
| color | Orange to Amber to Dark red |
| PH | pH (1g/l, 25℃) : 4.0～8.0 |
| Water Solubility | H2O: 10mg/mL |
| BRN | 3921806 |
| Stability | Hygroscopic |
| FDA UNII | 27V8M747VB |
| EPA Substance Registry System | 3,6-Acridinediamine, sulfate (2:1) (1811-28-5) |
| UNSPSC Code | 12171500 |
| NACRES | NA.47 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AR9065100 | |||||||||
| F | 3-8-10-23 | |||||||||
| HS Code | 2918.19.9000 | |||||||||
| Toxicity | mouse,LD50,subcutaneous,200mg/kg (200mg/kg),Quarterly Journal of Pharmacy & Pharmacology. Vol. 10, Pg. 649, 1937. | |||||||||
| NFPA 704 |
|
Proflavine hemisulfate price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P2508 | Proflavine hemisulfate salt hydrate powder | 1811-28-5 | 10g | $73.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | P2508 | Proflavine hemisulfate salt hydrate powder | 1811-28-5 | 1g | $18.8 | 2023-06-20 | Buy |
| TCI Chemical | D0073 | Proflavine Hemisulfate Hydrate >97.0%(N) | 1811-28-5 | 5g | $43 | 2024-03-01 | Buy |
| TCI Chemical | D0073 | Proflavine Hemisulfate Hydrate >97.0%(N) | 1811-28-5 | 25g | $117 | 2024-03-01 | Buy |
| Sigma-Aldrich | P2508 | Proflavine hemisulfate salt hydrate powder | 1811-28-5 | 25g | $159 | 2024-03-01 | Buy |
Proflavine hemisulfate Chemical Properties,Uses,Production
Description
Proflavine Hemisulfate, the hemisulfate form of proflavin, is an acridine-derived fluorescent contrast agent and disinfectant used for cell imaging and antiseptic purposes. Following topical application, proflavin diffuses into cells and intercalates into DNA, leading to its accumulation in and staining of the nucleus. This allows visualization of the nucleus during fluorescence imaging. Such capability enables nuclear morphometry and facilitates the identification of cancer cells. Additionally, proflavin sulfate exerts antimicrobial effects through binding to bacterial DNA, which disrupts DNA synthesis and inhibits bacterial cell growth.
Chemical Properties
orange to brown crystalline powder
Uses
An Acridine derivative with limited antifungal activity
Uses
Proflavine Hemisulfate is used in preparation of Adenine and Adenine nucleotides via photochemical demethylation of methyladenines.
in vivo
The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing[3].
| Animal Model: | Adult male Sprague Dawley rats (weighing approximately 200 g)[3] |
| Dosage: | 20 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing |
| Result: | Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease. |
Purification Methods
An aqueous solution, after treatment with charcoal, is concentrated, chilled overnight, filtered and the precipitate is rinsed with a little diethyl ether. The precipitate is dried in air, then overnight in a vacuum oven at 70o. [Beilstein 22 I 650, 22/11 V 323.]
Proflavine hemisulfate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49984 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
View Lastest Price from Proflavine hemisulfate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Proflavine Hemisulfate
1811-28-5
|
US $33.00-60.00 / mg | 99.55% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Proflavine Hemisulfate
1811-28-5
|
US $33.00-60.00 / mg | 99.55% | 10g | TargetMol Chemicals Inc. |
-
- Proflavine Hemisulfate
1811-28-5
- US $33.00-60.00 / mg
- 99.55%
- TargetMol Chemicals Inc.
-
- Proflavine Hemisulfate
1811-28-5
- US $33.00-60.00 / mg
- 99.55%
- TargetMol Chemicals Inc.