XMU-MP-1
- CAS No.
- 2061980-01-4
- Chemical Name:
- XMU-MP-1
- Synonyms
- 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide;CS-2590;XMU-MP-1;XUM-MP- 1;PubChem ID: 121499143;XMU MP 1,Inhibitor,Hippo (MST),inhibit,XMUMP1;4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide;Benzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-
- CBNumber:
- CB63122127
- Molecular Formula:
- C17H16N6O3S2
- Molecular Weight:
- 416.48
- MDL Number:
- MFCD30377214
- MOL File:
- 2061980-01-4.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |
XMU-MP-1 price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML2233 | XMU-MP-1 hydrochloride ≥98% (HPLC) | 2061980-01-4 | 5mg | $206 | 2024-03-01 | Buy |
Sigma-Aldrich | SML2233 | XMU-MP-1 hydrochloride ≥98% (HPLC) | 2061980-01-4 | 25mg | $328.8 | 2024-03-01 | Buy |
Cayman Chemical | 22083 | XMU-MP-1 ≥98% | 2061980-01-4 | 1mg | $78 | 2024-03-01 | Buy |
Cayman Chemical | 22083 | XMU-MP-1 ≥98% | 2061980-01-4 | 5mg | $175 | 2024-03-01 | Buy |
Cayman Chemical | 22083 | XMU-MP-1 ≥98% | 2061980-01-4 | 10mg | $308 | 2024-03-01 | Buy |
XMU-MP-1 Chemical Properties,Uses,Production
Description
XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2 (IC50s = 71.1 and 38.1 nM, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. It also prevents cell death induced by overexpression of MST2. XMU-MP-1 (1 mg/kg) enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury.
Uses
XMU-?MP-?1 an MST1/2 inhibitor.
storage
Store at -20°C
References
1. fuqin fan, zhixiang he, lu-lu kong, et al. pharmacological targeting of kinases mst1 and mst2 augments tissue repair and regeneration. science translational medicine 17 aug 2016: vol. 8, issue 352, pp. 352ra108.
XMU-MP-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Chemia Biotechnology(Shanghai) Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Suzhou Chukai Pharma Tech Co.,Ltd | +8615062531973 | 2279973922@qq.com | China | 365 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39010 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4196 | 58 |