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CRT0066101

CAS No.
1883545-60-5
Chemical Name:
CRT0066101
Synonyms
CS-2578;CRT0066101 hcl;CRT0066101 2HCL;CRT0066101 (CRT-0066101;CRT0066101 dihydrochloride;2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride;Inhibitor,CRT-0066101 dihydrochloride,CRT0066101,CRT0066101 dihydrochloride,Protein kinase D,CRT-0066101,CRT 0066101,PKD,inhibit
CBNumber:
CB63164875
Molecular Formula:
C18H23ClN6O
Molecular Weight:
374.87
MDL Number:
MOL File:
1883545-60-5.mol
Last updated:2024-10-28 16:48:35

CRT0066101 Properties

storage temp. Store at -20°C
solubility insoluble in H2O; ≥15.65 mg/mL in DMSO; ≥4.49 mg/mL in EtOH with ultrasonic
form solid
color Off-white to light yellow

CRT0066101 price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C782018 CRT0066101 1883545-60-5 5mg $280 2021-12-16 Buy
ApexBio Technology A8679 CRT0066101 1883545-60-5 10mg $150 2021-12-16 Buy
ApexBio Technology A8679 CRT0066101 1883545-60-5 10mM(in 1mL DMSO) $180 2021-12-16 Buy
ApexBio Technology A8679 CRT0066101 1883545-60-5 100mg $1800 2021-12-16 Buy
DC Chemicals DC20928 CRT0066101 >98% 1883545-60-5 1g $2500 2021-12-16 Buy
Product number Packaging Price Buy
C782018 5mg $280 Buy
A8679 10mg $150 Buy
A8679 10mM(in 1mL DMSO) $180 Buy
A8679 100mg $1800 Buy
DC20928 1g $2500 Buy

CRT0066101 Chemical Properties,Uses,Production

Biological Activity

crt 0066101 is a specific inhibitor of all pkd isoforms. increasingly studies reveals that pkd family members play an important role in regulating several cellular processes and activities, including chromatin organization, golgi function, gene expression, cell survival, adhesion, motility, differentiation, dna synthesis and proliferation. by suppressing pkd, crt 0066101 is supposed to ameliorate symptoms of pancreatic cancer. [1]

in vitro

in panc-1 cell line based assays, crt0066101 was reported to reduce bromodeoxyuridine incorporation; increase cell apoptosis; suppress neurotensin-induced pkd1/2 activation; block neurotensin-induced hsp27 phosphorylation; interrupt pkd1-mediated nf-κb activation as well as down-regulate expression of nf-κb-dependent proliferative and pro-survival proteins. [1]

in vivo

in panc-1 subcutaneous xenograft model, orally administration of crt0066101 at the dosage of 80 mg/kg/d for 24 days significantly suppressed pancreatic cancer growth. moreover, when crt0066101 reached its peak concentration (12 μmol/l) in tumor model, the expression of activated pkd1/2 in the treated tumor explants was substantially decreased. it was concluded that crt0066101 given orally at 80 mg/kg/d for 21 days in panc-1 orthotropic model suppressed tumor growth potently in vivo. [1]

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> PKD2
(Cell-free assay)
TargetValue
PKD1
(Cell-free assay)
1 nM
PKD3
(Cell-free assay)
2 nM
2.5 nM

IC 50

a potent protein kinase d (pkd) antagonist with the ic50 of 1, 2.5 and 2 nm for pkd1, pkd2, pkd3 respectively.

storage

Store at -20°C

References

[1]harikumar kb, kunnumakkara1 ab, ochi n, tong z, deorukhkar a, sung b, kelland l, jamieson s, sutherland r, raynham t, charles m, bagherzadeh a, foxton c, boakes a, farooq m, maru d, diagaradjane p, matsuo y, smith j, gelovani j, krishnan s, aggarwal bb, rozengurt e, ireson cr, and guha s. a novel small-molecule inhibitor of protein kinase d blocks pancreatic cancer growth in vitro and in vivo. mol cancer ther. 2010 may. 9(5): 113646.

CRT0066101 Preparation Products And Raw materials

Raw materials

Preparation Products

CRT0066101 Suppliers

Global( 65)Suppliers
Supplier Tel Email Country ProdList Advantage
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30241 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38463 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1841 55
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58

View Lastest Price from CRT0066101 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CRT0066101 dihydrochloride pictures 2024-10-28 CRT0066101 dihydrochloride
1883545-60-5
US $31.00-122.00 / mg 99.85% 10g TargetMol Chemicals Inc.

CRT0066101 Spectrum

CRT0066101 2HCL CRT0066101 dihydrochloride 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride CRT0066101 (CRT-0066101 CS-2578 CRT0066101 hcl Inhibitor,CRT-0066101 dihydrochloride,CRT0066101,CRT0066101 dihydrochloride,Protein kinase D,CRT-0066101,CRT 0066101,PKD,inhibit 1883545-60-5 C18H22N6O2HCl