CRT0066101
- CAS No.
- 1883545-60-5
- Chemical Name:
- CRT0066101
- Synonyms
- CS-2578;CRT0066101 hcl;CRT0066101 2HCL;CRT0066101 (CRT-0066101;CRT0066101 dihydrochloride;2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride;Inhibitor,CRT-0066101 dihydrochloride,CRT0066101,CRT0066101 dihydrochloride,Protein kinase D,CRT-0066101,CRT 0066101,PKD,inhibit
- CBNumber:
- CB63164875
- Molecular Formula:
- C18H23ClN6O
- Molecular Weight:
- 374.87
- MDL Number:
- MOL File:
- 1883545-60-5.mol
CRT0066101 price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | C782018 | CRT0066101 | 1883545-60-5 | 5mg | $280 | 2021-12-16 | Buy |
ApexBio Technology | A8679 | CRT0066101 | 1883545-60-5 | 10mg | $150 | 2021-12-16 | Buy |
ApexBio Technology | A8679 | CRT0066101 | 1883545-60-5 | 10mM(in 1mL DMSO) | $180 | 2021-12-16 | Buy |
ApexBio Technology | A8679 | CRT0066101 | 1883545-60-5 | 100mg | $1800 | 2021-12-16 | Buy |
Ambeed | A226191 | (R)-2-(4-((2-Aminobutyl)amino)pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenoldihydrochloride 98+% | 1883545-60-5 | 5mg | $119 | 2021-12-16 | Buy |
CRT0066101 Chemical Properties,Uses,Production
Biological Activity
crt 0066101 is a specific inhibitor of all pkd isoforms. increasingly studies reveals that pkd family members play an important role in regulating several cellular processes and activities, including chromatin organization, golgi function, gene expression, cell survival, adhesion, motility, differentiation, dna synthesis and proliferation. by suppressing pkd, crt 0066101 is supposed to ameliorate symptoms of pancreatic cancer. [1]
in vitro
in panc-1 cell line based assays, crt0066101 was reported to reduce bromodeoxyuridine incorporation; increase cell apoptosis; suppress neurotensin-induced pkd1/2 activation; block neurotensin-induced hsp27 phosphorylation; interrupt pkd1-mediated nf-κb activation as well as down-regulate expression of nf-κb-dependent proliferative and pro-survival proteins. [1]
in vivo
in panc-1 subcutaneous xenograft model, orally administration of crt0066101 at the dosage of 80 mg/kg/d for 24 days significantly suppressed pancreatic cancer growth. moreover, when crt0066101 reached its peak concentration (12 μmol/l) in tumor model, the expression of activated pkd1/2 in the treated tumor explants was substantially decreased. it was concluded that crt0066101 given orally at 80 mg/kg/d for 21 days in panc-1 orthotropic model suppressed tumor growth potently in vivo. [1]
target
Target | Value |
PKD1 (Cell-free assay) | 1 nM |
PKD3 (Cell-free assay) | 2 nM |
2.5 nM |
IC 50
a potent protein kinase d (pkd) antagonist with the ic50 of 1, 2.5 and 2 nm for pkd1, pkd2, pkd3 respectively.
storage
Store at -20°C
References
[1]harikumar kb, kunnumakkara1 ab, ochi n, tong z, deorukhkar a, sung b, kelland l, jamieson s, sutherland r, raynham t, charles m, bagherzadeh a, foxton c, boakes a, farooq m, maru d, diagaradjane p, matsuo y, smith j, gelovani j, krishnan s, aggarwal bb, rozengurt e, ireson cr, and guha s. a novel small-molecule inhibitor of protein kinase d blocks pancreatic cancer growth in vitro and in vivo. mol cancer ther. 2010 may. 9(5): 113646.
CRT0066101 Preparation Products And Raw materials
Raw materials
Preparation Products
CRT0066101 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1847 | 55 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
View Lastest Price from CRT0066101 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-11-19 | CRT0066101 dihydrochloride
1883545-60-5
|
US $31.00-122.00 / mg | 99.85% | 10g | TargetMol Chemicals Inc. |
- CRT0066101 dihydrochloride
1883545-60-5
- US $31.00-122.00 / mg
- 99.85%
- TargetMol Chemicals Inc.