2-Methoxyethoxymethyl chloride
- CAS No.
- 3970-21-6
- Chemical Name:
- 2-Methoxyethoxymethyl chloride
- Synonyms
- MEM CHLORIDE;1-CHLOROMETHOXY-2-METHOXYETHANE;MEMCl;MEM Chlordie;MEM chloride,94%;2-Methoxyethoxymethy;2-MethoxyethoxymethyL;Rosithromycinsidechain;1-Chloro-2,5-dioxahexane;Roxithromycin side chain
- CBNumber:
- CB6332734
- Molecular Formula:
- C4H9ClO2
- Molecular Weight:
- 124.57
- MDL Number:
- MFCD00000888
- MOL File:
- 3970-21-6.mol
- MSDS File:
- SDS
| Melting point | 200-202 °C |
|---|---|
| Boiling point | 50-52 °C/13 mmHg (lit.) |
| Density | 1.091 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Methanol |
| form | Liquid |
| Specific Gravity | 1.091 |
| color | Clear colorless to yellow |
| Water Solubility | It hydrolyzes with water. |
| Sensitive | Moisture Sensitive |
| BRN | 1900576 |
| Exposure limits | ACGIH: TWA 0.001 ppm |
| InChIKey | BIAAQBNMRITRDV-UHFFFAOYSA-N |
| CAS DataBase Reference | 3970-21-6(CAS DataBase Reference) |
| FDA UNII | A5RRM67QUG |
| NIST Chemistry Reference | «BETA»-methoxyethoxymethyl chloride(3970-21-6) |
| EPA Substance Registry System | Ethane, 1-(chloromethoxy)-2-methoxy- (3970-21-6) |
| UNSPSC Code | 12352101 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H302-H315-H319-H331-H335-H350 | |||||||||
| Precautionary statements | P210-P301+P312-P303+P361+P353-P304+P340+P311-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 45-10-36/37/38-20/21/22-46-40-23/24/25-20/22 | |||||||||
| Safety Statements | 53-26-36/37/39-45-16-23 | |||||||||
| RIDADR | UN 2810 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Toxic | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29091990 | |||||||||
| NFPA 704 |
|
2-Methoxyethoxymethyl chloride price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 357480 | 2-Methoxyethoxymethyl chloride technical grade | 3970-21-6 | 5g | $77.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 357480 | 2-Methoxyethoxymethyl chloride technical grade | 3970-21-6 | 25g | $194 | 2024-03-01 | Buy |
| TCI Chemical | M0680 | 2-Methoxyethoxymethyl Chloride >95.0%(GC) | 3970-21-6 | 25mL | $78 | 2024-03-01 | Buy |
| TCI Chemical | M0680 | 2-Methoxyethoxymethyl Chloride >95.0%(GC) | 3970-21-6 | 500mL | $597 | 2024-03-01 | Buy |
| Alfa Aesar | L01050 | 2-Methoxyethoxymethyl chloride, 94% | 3970-21-6 | 5g | $45.65 | 2024-03-01 | Buy |
2-Methoxyethoxymethyl chloride Chemical Properties,Uses,Production
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
OH-protecting reagent. MEM ethers are stable to a variety of reaction conditions and are selectively cleaved under aprotic conditions in the presence of a wide rangeof OH-protected moieties.
Uses
2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ?-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.
Uses
2-Methoxyethoxymethyl Chloride is an OH-protecting reagent. 2-Methoxyethoxymethyl Chloride is used in the modification of antibiotics.
Purification Methods
Possible impurities are methoxyethanol (b 124o/atm), HCHO and HCl which can be removed below the boiling point of MEMCl. Purify MEMCl by fractional distillation in a vacuum. If too impure, prepare it from methoxyethanol (152g) and s-trioxane (66g) by bubbling a stream of dry HCl (with stirring) until a clear mixture is obtained. Dilute with pentane (900mL), dry (3hours over 100g MgSO4, at 5o), evaporate and the residue is distilled in a vacuum. It is MOISTURE SENSITIVE and TOXIC. The MEM.NEt3+Cl-salt, prepared by reaction with 1.3 equivalents of Et3N (16hours/25o) and dried in a vacuum, has m 58-61o, and is moisture sensitive. [Corey et al. Tetrahedron Lett 809 1976, Yoshimatsu et al. J Org Chem 59 1011 1994, Greene & Wuts Protective Groups in Organic Synthesis edn, J Wiley & Sons NY 1991.] Carcinogen.
2-Methoxyethoxymethyl chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18137 | 58 |
| airuikechemical co., ltd. | +86-18353166132 +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19809 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29859 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6383 | 58 |
View Lastest Price from 2-Methoxyethoxymethyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-15 | 2-Methoxyethoxymethyl chloride
3970-21-6
|
US $30.00-10.00 / KG | 50KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-03-21 | 2-Methoxyethoxymethyl chloride
3970-21-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2024-12-24 | 2-methoxyethoxymethyl chloride
3970-21-6
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. |
-
- 2-Methoxyethoxymethyl chloride
3970-21-6
- US $30.00-10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Methoxyethoxymethyl chloride
3970-21-6
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 2-methoxyethoxymethyl chloride
3970-21-6
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.