ChemicalBook >> CAS DataBase List >>5-Fluorouridine
5-Fluorouridine
- CAS No.
- 316-46-1
- Chemical Name:
- 5-Fluorouridine
- Synonyms
- FUR;5-FU;FURD;5-fur;5-FUrd;NSC 146604;NSC 519273;FLUOROURIDINE;5-FLUOROIDINE;5-fluoro-uridin
- CBNumber:
- CB6346346
- Molecular Formula:
- C9H11FN2O6
- Molecular Weight:
- 262.19
- MDL Number:
- MFCD00036832
- MOL File:
- 316-46-1.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
| Melting point | 182-184 °C |
|---|---|
| alpha | 17 º (c=2, water 25 ºC) |
| Density | 1.4200 (estimate) |
| refractive index | 18 ° (C=1, H2O) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming) |
| form | Powder |
| pka | 7.63±0.10(Predicted) |
| color | White |
| biological source | synthetic (organic) |
| Water Solubility | soluble |
| BRN | 33662 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 316-46-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4K0M952561 |
| UNSPSC Code | 41106305 |
| NACRES | NA.51 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H341-H373 |
| Precautionary statements | P201-P202-P260-P280-P308+P313-P405-P501-P501a |
| Hazard Codes | Xn,Xi |
| Risk Statements | 40-68-36/37/38 |
| Safety Statements | 22-26-36/37-36/37/39-27-24/25 |
| WGK Germany | 3 |
| RTECS | YU8050000 |
| F | 10 |
| Hazard Note | Harmful |
| HS Code | 29349990 |
5-Fluorouridine price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F5130 | 5-Fluorouridine proapoptotic anitproliferative plant growth regulator | 316-46-1 | 100mg | $124 | 2024-03-01 | Buy |
| Sigma-Aldrich | F5130 | 5-Fluorouridine proapoptotic anitproliferative plant growth regulator | 316-46-1 | 1g | $683 | 2024-03-01 | Buy |
| TCI Chemical | F0636 | 5-Fluorouridine >98.0%(T) | 316-46-1 | 1g | $50 | 2024-03-01 | Buy |
| TCI Chemical | F0636 | 5-Fluorouridine >98.0%(T) | 316-46-1 | 5g | $149 | 2024-03-01 | Buy |
| Alfa Aesar | J62083 | 5-Fluorouridine, 97% | 316-46-1 | 1g | $56.65 | 2024-03-01 | Buy |
5-Fluorouridine Chemical Properties,Uses,Production
Description
5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1? Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.
Chemical Properties
White Powder
Uses
5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.
Uses
Antihypertensive
Uses
5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750).
Definition
ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.
General Description
5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.
Biochem/physiol Actions
5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.
Purification Methods
5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]
References
1) Yen et al. (2006), Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries; RNA, 12 797 2) Schmittgen et al. (2005), Diverse gene expression pattern during 5-fluorouridine-induced apoptosis; Int. J. Oncol., 27 297
5-Fluorouridine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 232)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29792 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49476 | 58 |
View Lastest Price from 5-Fluorouridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 5-Fluorouridine
316-46-1
|
US $39.00-55.00 / mg | 99.76% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | 5-Fluorouridine
316-46-1
|
US $39.00-55.00 / mg | 99.76% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-02 | 5-Fluorouridine
316-46-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-Fluorouridine
316-46-1
- US $39.00-55.00 / mg
- 99.76%
- TargetMol Chemicals Inc.
-
- 5-Fluorouridine
316-46-1
- US $39.00-55.00 / mg
- 99.76%
- TargetMol Chemicals Inc.
-
- 5-Fluorouridine
316-46-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
316-46-1(5-Fluorouridine )Related Search:
5-Fluorouracil
5-Fluorouridine
Floxuridine
2'-DEOXY-2'-FLUOROURIDINE,2''-DEOXY-2''-FLUOROURIDINE (2''-FLUORO-2''- DEOXYURIDINE)
5'-DEOXY-5-FLUOROURIDINE
DMT-2′Fluoro-dU Phosphoramidite
Uracil
5-Fluoropyrimidine
5'-Deoxy-2',3'-O-isopropylidene-5-fluorouridine
2',3'-DIDEOXY-3'-FLUOROURIDINE
1of4
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1
5-fluoro-uridin
5-fur
Uridine, 5-fluoro-
FURD
FLUOROURIDINE
1-(3,4-DIHYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-FLUORO-1H-PYRIMIDINE-2,4-DIONE
5-FLUORO-1-(BETA-D-RIBOFURANOSYL)URACIL
5-FU
5-FLUOROURACIL-1BETA-D-RIBOFURANOSIDE
2,4-DIHYDROXY-5-FLUORO-1-BETA-D-RIBOFURANOSYLPYRIMIDINE
5-fluorouracil 1β-d-ribofuranoside
5-Fluorouridine97%
5-FLUOROURIDINE, 98+%
5-Fluorouridine
5-FLUOROIDINE
(2'R,3'R,4'S,5'R)-1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione
1-(beta-D-Ribofuranosyl)-5-fluorouracil
5-FLUOROURIDINE extrapure
5-Fluorouracil 1β-D-ribofuranoside, FUrd
1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione
5-FLUOROURIDINE, 99+%
FUR
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-fluoropyriMidine-2,4(1H,3H)-dione
5-FUrd
NSC 146604
NSC 519273
FUrd
1-(beta-D-Ribofuranosyl)-5-fluorouracil
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3
5-Fluorouridine>
5-Fluorouridine USP/EP/BP
5-Fluorouridine (5-FUrd) extrapure, 98%
1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-fluoropyrimidine-2,4-dione
5-Fluorouridine, impurity of 5-fluorouracil
5- fluorouracil nucleoside
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
5-Fluorouridine, 10 mM in DMSO
316-46-1
C9H11FN2O6
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