L-Citrulline
- CAS No.
- 372-75-8
- Chemical Name:
- L-Citrulline
- Synonyms
- CITRULLINE;(S)-2-AMINO-5-UREIDOPENTANOIC ACID;H-CIT-OH;L-CITRULINE;L-CIT;L-Cit-OH;L-Citrullin;L-Citrullne;N5-(aminocarbonyl)-L-Ornithine;L-CTRULLINE
- CBNumber:
- CB6423883
- Molecular Formula:
- C6H13N3O3
- Molecular Weight:
- 175.19
- MDL Number:
- MFCD00064397
- MOL File:
- 372-75-8.mol
- MSDS File:
- SDS
| Melting point | 214 °C |
|---|---|
| alpha | 25.5 º (c=8, 6N HCl) |
| Boiling point | 306.48°C (rough estimate) |
| Density | 1.2919 (rough estimate) |
| refractive index | 26 ° (C=8, 6mol/L HCl) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Aqueous Acid (Sparingly). Water (Slightly) |
| pka | 2.43(at 25℃) |
| form | Crystals or Crystalline Powder |
| color | White |
| Odor | Odorless |
| optical activity | +4.025 (H2O) +24.225 (1 mol dm-3 HCl) |
| Water Solubility | 200 g/L (20 ºC) |
| Merck | 14,2331 |
| BRN | 6055157 |
| InChIKey | RHGKLRLOHDJJDR-BYPYZUCNSA-N |
| LogP | -3.190 |
| CAS DataBase Reference | 372-75-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 29VT07BGDA |
| NCI Drug Dictionary | L-citrulline |
| EPA Substance Registry System | L-Ornithine, N5-(aminocarbonyl)- (372-75-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29241900 | |||||||||
| NFPA 704 |
|
L-Citrulline price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3191 | L-Citrulline pharmaceutical secondary standard, certified reference material | 372-75-8 | 500MG | $200 | 2024-03-01 | Buy |
| Sigma-Aldrich | C7629 | L-Citrulline ≥98% (TLC) | 372-75-8 | 1kg | $3000 | 2024-03-01 | Buy |
| Sigma-Aldrich | 19936 | L-Citrulline certified reference material, TraceCERT? | 372-75-8 | 10MG | $84.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1133842 | L-Citrulline United States Pharmacopeia (USP) Reference Standard | 372-75-8 | 200mg | $467 | 2024-03-01 | Buy |
| TCI Chemical | C0372 | L-Citrulline >98.0%(T) | 372-75-8 | 25g | $27 | 2024-03-01 | Buy |
L-Citrulline Chemical Properties,Uses,Production
Chemical Properties
White powder
Originator
StaminO2,ErgoPharm
Uses
L-Citrulline, is used as an essential intermediate in the biosynthesis of nitric oxide from L-arginine . It is also used as a nutritional drink and biochemical reagent.
Uses
An amino acid, L-Citrulline can be used in the treatment of asthenia and as an essential intermediate in the biosynthesis of nitric oxide.
Definition
ChEBI: L-citrulline is the L-enantiomer of citrulline. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a protective agent, a nutraceutical, a micronutrient, a human metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is an enantiomer of a D-citrulline. It is a tautomer of a L-citrulline zwitterion.
Manufacturing Process
Citrulline is obtained as a result of a reaction of L-arginine hydrochloride with
sodium hydroxide, copper oxide and hydrogen sulfide.
In practice it is usually used as malate salt
Therapeutic Function
Stimulant, Detoxicant
benefits
L-citrulline is used for Alzheimer's disease, dementia, fatigue, muscle weakness, sickle cell disease, erectile dysfunction, high blood pressure, and diabetes. It is used for heart disease, body building, increasing energy, and for improving athletic performance.
Biochem/physiol Actions
L-Citrulline, when orally administered is found to ameliorate the condition of sickle cell disease in humans. L-citrulline can be a replacement for L-arginine administration in case of defective NO synthetase. L-Citrulline supplementation is found to fulfill the purpose of NO-dependent signaling.
target
NO | IL Receptor
Drug interactions
There are no reported side effects of L-citrulline.
However, the supplement may affect the way certain drugs work in your body. Do not take this supplement if you are taking:
Nitrates for heart disease
ED drugs such as sildenafil (Revatio, Viagra), tadalafil (Cialis), or vardenafil (Levitra, Staxyn)
Combining L-citrulline with those drugs may cause a dangerous drop in blood pressure.
You should also be careful when taking L-citrulline if you take any type of blood pressure medicine.
Do not use L-citrulline if you are pregnant or breastfeeding.
Purification Methods
Likely impurities are arginine and ornithine. Crystallise S-citrulline from water by adding 5 volumes of EtOH. Also crystallise it from water by addition of MeOH. [Ellenbogen J Am Chem Soc 74 5198 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2491-2494 1961, Beilstein 4 IV 2647.]
L-Citrulline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
| DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9363 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
| Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3096 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5978 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 902 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18154 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3010 | 58 |
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Related Qustion
- Q:Which food is rich in L-citrulline?
- A:L-citrulline, an α-amino acid, contributes to Nitric oxide (NO) synthesis through this NOS-dependent pathway via its conversio....
- Sep 5，2024
View Lastest Price from L-Citrulline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-24 | L-Citrulline
372-75-8
|
US $15.00 / kg | 1kg | ≥98% | 3000tons/month | Hebei Andu Technology Com.,Ltd | |
 |
2024-11-24 | L-Citrulline
372-75-8
|
US $1.00 / kg | 1kg | 99% | 10 tons | Dorne Chemical Technology co. LTD | |
 |
2024-11-22 | L-(+)-2-Amino-5-ureidovaleric acid
372-75-8
|
US $70.00 / kg | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co.,Ltd |
-
- L-Citrulline
372-75-8
- US $15.00 / kg
- ≥98%
- Hebei Andu Technology Com.,Ltd
-
- L-Citrulline
372-75-8
- US $1.00 / kg
- 99%
- Dorne Chemical Technology co. LTD
-
- L-(+)-2-Amino-5-ureidovaleric acid
372-75-8
- US $70.00 / kg
- 99
- Hebei Zhuanglai Chemical Trading Co.,Ltd