PyBOP
- CAS No.
- 128625-52-5
- Chemical Name:
- PyBOP
- Synonyms
- PYBOP;BOPP;BOP REAGENT;((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V);(BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE;BENZOTRIAZOLE-1-YL-OXY-TRIS-PYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE;1H-BENZOTRIAZOL-1-YLOXYTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE;[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate;BYPOP;PYBOP(R)
- CBNumber:
- CB6434717
- Molecular Formula:
- C18H28F6N6OP2
- Molecular Weight:
- 520.39
- MDL Number:
- MFCD00077411
- MOL File:
- 128625-52-5.mol
- MSDS File:
- SDS
| Melting point | 154-156 °C (dec.)(lit.) |
|---|---|
| Density | 1.438 at 20℃ |
| vapor pressure | 0-0Pa at 20-50℃ |
| storage temp. | 2-8°C |
| solubility | methanol: 25 mg/mL, clear |
| form | Fine Crystalline Powder |
| color | White to off-white |
| Sensitive | Moisture Sensitive |
| BRN | 3584612 |
| InChI | InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1 |
| InChIKey | BYCLGHOAELJLOF-UHFFFAOYSA-M |
| SMILES | [P+](ON1N=NC2C=CC=CC1=2)(N1CCCC1)(N1CCCC1)N1CCCC1.[P-](F)(F)(F)(F)(F)F |
| LogP | -0.3 at 26℃ and pH3.5-3.7 |
| CAS DataBase Reference | 128625-52-5(CAS DataBase Reference) |
| UNSPSC Code | 12352107 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H410 | |||||||||
| Precautionary statements | P261-P264-P273-P280-P301+P312-P302+P352 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-44-36/37/38 | |||||||||
| Safety Statements | 26-36-24/25-37/39 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-21 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339980 | |||||||||
| NFPA 704 |
|
PyBOP price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.51009 | PyBOP Novabiochem? | 128625-52-5 | 25g | $123 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.51009 | PyBOP Novabiochem? | 128625-52-5 | 100g | $367 | 2024-03-01 | Buy |
| Sigma-Aldrich | 12805 | (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate purum, ≥97.0% (TLC) | 128625-52-5 | 1g | $81.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 12805 | (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate purum, ≥97.0% (TLC) | 128625-52-5 | 5G | $96 | 2024-03-01 | Buy |
| Sigma-Aldrich | 12805 | (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate purum, ≥97.0% (TLC) | 128625-52-5 | 25g | $298 | 2024-03-01 | Buy |
PyBOP Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
One of the most convenient coupling reagents for peptide synthesis without carcinogenic by-products. It replaces BOP reagent. This is especially suitable for solid-phase peptide synthesis, avoids racemization.
Uses
1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate (PyBOP) is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.
Uses
PyBOP is a reagent for:
Synthesis of single labeled oligonucleotides that fluoresce upon matched hybridization
Generation of endocrine disruptor chemical binders
Cycloaddition to template-assembled multivalent peptide conjugates
Definition
PyBOP (benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) coupling reagent was selected for the peptidic bond formation. This selection was because PyBOP is efficient and could generate less toxic byproducts. PyBOP is an efficient coupling reagent utilized in solid-phase peptide synthesis. It reacts similarly to BOP, but its byproduct is not highly carcinogenic. PyBOP was utilized in the solid-phase synthesis of the tetrapeptide H-Ile-Ala-Leu-Pro-OH on 2-chlorotrityl resin. In contrast to uronium-based coupling reagents, PyBOP does not form guanidinated byproducts when used in excess. This makes it useful in fragment condensation reactions and head-to-tail cyclizations[1].
General Description
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.
reaction suitability
reaction type: Coupling Reactions
References
[1] Maharani, R. et al. “Good coupling performance of PyBOP in the solid-phase synthesis of tetrapeptide, OH-Pro-Leu-Ala-Ileu-NH2.” 2017. 0.
PyBOP Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Vcan Advanced Material Co., Ltd. | +86-17306299870 +86-18652789875 | vcanam@vcanam.com | China | 38 | 58 |
| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18137 | 58 |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | sales01@watsonbiotech.cn | China | 5849 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19805 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
View Lastest Price from PyBOP manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-25 | PyBOP Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
128625-52-5
|
US $0.00-0.00 / kg | 1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd | |
 |
2025-04-24 | Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
128625-52-5
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-23 | Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
128625-52-5
|
US $25.00 / ASSAYS | 100ASSAYS | 99.5% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- PyBOP Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
128625-52-5
- US $0.00-0.00 / kg
- 99%
- Watson Biotechnology Co.,Ltd
-
- Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
128625-52-5
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
128625-52-5
- US $25.00 / ASSAYS
- 99.5%
- Hebei Chuanghai Biotechnology Co., Ltd
128625-52-5(PyBOP)Related Search:
1of4