4',7-DIMETHOXY-5-HYDROXYFLAVONE
- CAS No.
- 5128-44-9
- Chemical Name:
- 4',7-DIMETHOXY-5-HYDROXYFLAVONE
- Synonyms
- Dimethoxylapigenin;4',7-DIMETHOXYAPIGENIN;apigenin dimethylether;4’7-Dimethoxylapigenin;4'-Di-O-methylapigenin;4',7-O-DIMETHYLAPIGENIN;7,4'-Di-O-methylapigenin;ACACETIN 7-O-METHYL ETHER;Genkwanin 4'-methyl ether;7,4''-Di-O-methylapigenin
- CBNumber:
- CB6447665
- Molecular Formula:
- C17H14O5
- Molecular Weight:
- 298.29
- MDL Number:
- MFCD00017446
- MOL File:
- 5128-44-9.mol
| Melting point | 139-140 °C |
|---|---|
| Boiling point | 515.2±50.0 °C(Predicted) |
| Density | 1.321±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO : 5 mg/mL (16.76 mM; Need ultrasonic) |
| form | powder |
| pka | 6.35±0.40(Predicted) |
| color | Yellow |
| LogP | 3.444 (est) |
| FDA UNII | LVC8MF8MWR |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4',7-DIMETHOXY-5-HYDROXYFLAVONE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FA65396 | Acacetin 7-O-methyl ether | 5128-44-9 | 5mg | $82.5 | 2021-12-16 | Buy |
| AK Scientific | W1635 | 7,4'-Di-O-methylapigenin | 5128-44-9 | 2mg | $103 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA65396 | Acacetin 7-O-methyl ether | 5128-44-9 | 10mg | $130 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA65396 | Acacetin 7-O-methyl ether | 5128-44-9 | 2mg | $40 | 2021-12-16 | Buy |
| AK Scientific | W1635 | 7,4'-Di-O-methylapigenin | 5128-44-9 | 10mg | $223 | 2021-12-16 | Buy |
4',7-DIMETHOXY-5-HYDROXYFLAVONE Chemical Properties,Uses,Production
Uses
The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
Definition
ChEBI: A dimethoxyflavone that is the 7,4'-dimethyl ether derivative of apigenin.
IC 50
Human Endogenous Metabolite
References
[1] Alvarez, M.E. et al.Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum. ex Moldenke.Farmaco. Jun-Jul;55(6-7):502-5.doi:10.1016/S0014-827X(00)00067-7(2000). DOI:10.1016/s0014-827x(00)00067-7
[2] Mangoyi, R., Midiwo, J. & Mukanganyama, S. Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri. BMC complementary and alternative medicine 15, 405, doi:10.1186/s12906-015-0934-7 (2015). DOI:10.1186/s12906-015-0934-7
4',7-DIMETHOXY-5-HYDROXYFLAVONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 3954 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32222 | 58 |
View Lastest Price from 4',7-DIMETHOXY-5-HYDROXYFLAVONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 7,4'-Di-O-methylapigenin
5128-44-9
|
US $39.00-123.00 / mg | 99.4% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-02-14 | 4',7-Dimethoxy-5-Hydroxyflavone 5128-44-9
5128-44-9
|
US $18.50 / mg | 20mg | ≥98% | 1000.00 kgs | NanJing Spring & Autumn Biological Engineering CO., LTD. | |
 |
2020-01-10 | apigenin 7,4'-dimethyl ether
5128-44-9
|
US $9.80 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- 7,4'-Di-O-methylapigenin
5128-44-9
- US $39.00-123.00 / mg
- 99.4%
- TargetMol Chemicals Inc.
-
- 4',7-Dimethoxy-5-Hydroxyflavone 5128-44-9
5128-44-9
- US $18.50 / mg
- ≥98%
- NanJing Spring & Autumn Biological Engineering CO., LTD.
-
- apigenin 7,4'-dimethyl ether
5128-44-9
- US $9.80 / KG
- ≥98%
- Career Henan Chemical Co
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