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H1152, DIHYDROCHLORIDE

CAS No.
871543-07-6
Chemical Name:
H1152, DIHYDROCHLORIDE
Synonyms
H-1152 2HCl;H1152, DIHYDROCHLORIDE;H-1152 2HCl|||H-1152 dihydrochloride;H 1152 DIHYDROCHLORIDE; H1152 DIHYDROCHLORIDE;4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline;(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride;H1152P2HCl,(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazineDihydrochloride;H1152P Dihydrochloride, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride
CBNumber:
CB6506731
Molecular Formula:
C16H21N3O2S
Molecular Weight:
319.42184
MDL Number:
MFCD06411451
MOL File:
871543-07-6.mol
Last updated:2024-07-12 17:58:41

H1152, DIHYDROCHLORIDE Properties

Melting point 182-184°C
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility Methanol, Water
form Solid
color White to Off-White
Stability Hygroscopic

H1152, DIHYDROCHLORIDE price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 555550 Rho Kinase Inhibitor - Calbiochem TheRhokinaseinhibitor,CAS872543-07-6,isacell-permeable,highlyspecific, 871543-07-6 1mg $324 2024-03-01 Buy
Sigma-Aldrich 555550 Rho Kinase Inhibitor - Calbiochem TheRhokinaseinhibitor,CAS872543-07-6,isacell-permeable,highlyspecific, 871543-07-6 5mg $659 2024-03-01 Buy
Tocris 2414 H1152dihydrochloride ≥98%(HPLC) 871543-07-6 1 $231 2021-12-16 Buy
TRC H011520 H-1152Dihydrochloride 871543-07-6 5mg $150 2021-12-16 Buy
TRC H011520 H-1152Dihydrochloride 871543-07-6 25mg $695 2021-12-16 Buy
Product number Packaging Price Buy
555550 1mg $324 Buy
555550 5mg $659 Buy
2414 1 $231 Buy
H011520 5mg $150 Buy
H011520 25mg $695 Buy

H1152, DIHYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compoud that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine

Uses

ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.

Definition

ChEBI: (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride is a hydrochloride salt resulting from the reaction of (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane with 2 mol eq. of hydrogen chloride. An ATP-competitive inhibitor of Rho kinase (ROCK). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It contains a (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane(2+).

General Description

A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27 μM for PKC, and 10.1 μM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50 = 2.5 μM) in NT-2 cells. Reported to be more potent and selective than Y-27632 (Cat. Nos. 688000 and 688001). Mainly targets Aurora Kinase A, and induces polyploidization of acute megakaryocytic leukemia cells (AMKL). At 10 mM (500 μg/128 μl) solution of Rho Kinase Inhibitor (Cat. No. 555552) in H2O is also available.

Biochem/physiol Actions

Primary TargetROCK

storage

Desiccate at +4°C

H1152, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

H1152, DIHYDROCHLORIDE Suppliers

Global( 52)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Chuchang Biotech Co., Ltd.
+undefined15623860702 info@chuchangbiotech.com China 116 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2782 58
SPIRO PHARMA eric_feng1954@126.com China 9248 55

View Lastest Price from H1152, DIHYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
H1152 pictures 2024-11-19 H1152
871543-07-6
US $0.00-0.00 / MG 1MG 99 20G Hubei Chuchang Biotech Co., Ltd.
  • H1152 pictures
  • H1152
    871543-07-6
  • US $0.00-0.00 / MG
  • 99
  • Hubei Chuchang Biotech Co., Ltd.

H1152, DIHYDROCHLORIDE Spectrum

5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline H1152, DIHYDROCHLORIDE H1152P2HCl,(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazineDihydrochloride H1152P Dihydrochloride, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride 4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline H-1152 2HCl H 1152 DIHYDROCHLORIDE; H1152 DIHYDROCHLORIDE H-1152 2HCl|||H-1152 dihydrochloride (S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride 871543-07-6 C16H23Cl2N3O2S Protein Kinase Inhibitors and Activators Inhibitors All Inhibitors Intermediates & Fine Chemicals Pharmaceuticals