Adenosine 5'-diphosphoribose sodium salt
- CAS No.
- 68414-18-6
- Chemical Name:
- Adenosine 5'-diphosphoribose sodium salt
- Synonyms
- adp-ribose;ADP ribose sodium;Adenosine 5'-diphosphoribose sodium;adenosine 5'-diphosphoribose sodium;ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT;ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT;Adenosine 5'-diphosphoribose sodium salt >=93%;ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT 2-HYDRATE;ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE;Adenosine 5'-diphosphoribose sodium|||ADP ribose sodium
- CBNumber:
- CB6667689
- Molecular Formula:
- C15H22N5NaO14P2
- Molecular Weight:
- 581.3
- MDL Number:
- MFCD30537216
- MOL File:
- 68414-18-6.mol
storage temp. | -20°C |
---|---|
form | Solid |
color | White to light yellow |
Water Solubility | Water : 125 mg/mL (215.04 mM) |
InChIKey | MBPRZUBFEMLFGQ-UUIVKEFHSA-M |
SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,15,17,19,24,r| |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
Adenosine 5'-diphosphoribose sodium salt price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A0752 | Adenosine 5′-diphosphoribose sodium salt ≥93% | 68414-18-6 | 25mg | $97.6 | 2024-03-01 | Buy |
Sigma-Aldrich | A0752 | Adenosine 5′-diphosphoribose sodium salt ≥93% | 68414-18-6 | 100mg | $298 | 2024-03-01 | Buy |
Sigma-Aldrich | A0752 | Adenosine 5′-diphosphoribose sodium salt ≥93% | 68414-18-6 | 500mg | $1180 | 2024-03-01 | Buy |
American Custom Chemicals Corporation | NUC0000507 | ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE 95.00% | 68414-18-6 | 500MG | $1286.73 | 2021-12-16 | Buy |
ChemScene | CS-0020654 | Adenosine5′-diphosphoribose(sodium) ≥98.0% | 68414-18-6 | 10mg | $120 | 2021-12-16 | Buy |
Adenosine 5'-diphosphoribose sodium salt Chemical Properties,Uses,Production
Description
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator and can also enhance autophagy.
Uses
5′-Deoxy-5′-(methylthio)adenosine has been used:
- to give a range of nicotinamide adenine dinucleotide (NADH)
- oxidation rates for the respiratory complex (CI/CIII/CIV)
- CI/alternative(AOX) pathway
- to measure poly(ADP-ribose) glycohydrolaseactivity
- poly(ADP-ribose) (PAR) binding competition assay
- oxidase?(AOX) pathway
- to measure poly(ADP-ribose) glycohydrolase activity
- poly(ADP-ribose) (PAR) binding competition assay
Biochem/physiol Actions
ADP-Ribose is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are an important components of DNA repair and apoptosis signaling.
in vitro
In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.
Adenosine 5'-diphosphoribose sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
Adenosine 5'-diphosphoribose sodium salt Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Maintain Biotech Co., Ltd. | +86-75589664337 +86-15112661142 | cami@maintain-bio.com | China | 66 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Maintain Biotech Co., Ltd. | 755-89664337 19125366885 | sales@maintain-bio.com | China | 51 | 58 |
Wuhan Haizheng Industry & Trade Development Co. Ltd | 027-8866 0053/88660577/88660578 | China | 1076 | 55 | |
Wuhan Taiyicheng Biopharmaceutical Co., Ltd. | 027-88320699 | tycshyy@126.com | China | 297 | 66 |