ChemicalBook >> CAS DataBase List >>5-Bromo-7-azaindole

5-Bromo-7-azaindole

5-Bromo-7-azaindole structure

CAS No.: 183208-35-7

Chemical Name:: 5-Bromo-7-azaindole

Synonyms: 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE;3-Bromo-7H-pyrrolo[2,3-b]pyridine;SW-57;SWF-57;SKL277;EOS-60661;5-BROMO AZAINDOLE;5-bromo-7-azindole;5-BROMO-7-AZAINDOLE;5-Bromo-7-azaindole,96%

CBNumber:: CB6756981

Molecular Formula:: C7H5BrN2

Molecular Weight:: 197.03

MDL Number:: MFCD06659677

MOL File:: 183208-35-7.mol

MSDS File:: SDS

Last updated:2024-11-22 13:21:06

Request For Quotation

5-Bromo-7-azaindole Properties

Melting point	176-180 °C
Boiling point	357.4±42.0 °C(Predicted)
Density	1.79±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	6.25±0.20(Predicted)
form	Crystalline Powder
color	White to yellow
InChI	InChI=1S/C7H5BrN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10)
InChIKey	LPTVWZSQAIDCEB-UHFFFAOYSA-N
SMILES	C12NC=CC1=CC(Br)=CN=2
LogP	1.8 at 25℃ and pH7
CAS DataBase Reference	183208-35-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H318

Precautionary statements

P280-P301+P312+P330-P305+P351+P338+P310

Hazard Codes

Xi,Xn

Risk Statements

22-41

Safety Statements

26-39

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
2		0

5-Bromo-7-azaindole price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	692549	5-Bromo-7-azaindole 97%	183208-35-7	5g	$200	2024-03-01	Buy
Sigma-Aldrich	692549	5-Bromo-7-azaindole 97%	183208-35-7	1g	$49.9	2023-06-20	Buy
TCI Chemical	B3588	5-Bromo-1H-pyrrolo[2,3-b]pyridine >98.0%(GC)(T)	183208-35-7	1g	$39	2024-03-01	Buy
TCI Chemical	B3588	5-Bromo-1H-pyrrolo[2,3-b]pyridine >98.0%(GC)(T)	183208-35-7	5g	$117	2024-03-01	Buy
Alfa Aesar	H50040	5-Bromo-7-azaindole, 96%	183208-35-7	1g	$52.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
692549	5g	$200	Buy
692549	1g	$49.9	Buy
B3588	1g	$39	Buy
B3588	5g	$117	Buy
H50040	1g	$52.65	Buy

5-Bromo-7-azaindole Chemical Properties,Uses,Production

Chemical Properties

White to light brown powder or crystal

Uses

5-Bromo-7-azaindole is a chemical reagent used in organic syntheses. Used in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. Also used in other 7-azaindole derivatives such as for PDK1 inihibtors.

Synthesis

In the 250 ml flask is sequentially added in 50 ml ethanol and 5-bromo-1-hydrogen pyrrolo [2,3 - the b] pyridine -2 - ketone (4.2g, 20 mmol), Sn powder (4.7 g, 40 mmol) and 5 mol/L hydrochloric acid (14 ml), 40 ℃ stirring for 2 hours, the reaction is completed, to remove the ethanol, add 50 ml of water residue is completely dissolved, saturated NaHCO3 solution and to pH=8, and filtering the resulting solid, after drying, dissolved in 50 ml chloroform, adding CuBr2(13.4 g, 60mmol), 60 Cstirring for 2 hours, the reaction is completed, the end of the reaction, rotary evaporated to remove chloroform, adding 50 ml saturated NaHCO3 solution, ethyl acetate (3 × 100 ml), the combined organic phase with water (50 ml) for washing and then the saturated salt water (50 ml) washing, anhydrous Na2SO4 drying, filtering, the filtrate is concentrated to obtain 5-bromo-1H-pyrrolo [2,3 - the b] pyridine the crude product, the crude product is chloroform: hexane=2:1 (volume ratio) mixed solution recrystallize to get 3.1 g of pale yellow 5-Bromo-7-azaindole pure product, yield 77.6%, melting point:176.8-177.3 ℃.

Solubility in organics

The solubility of 5-Bromo-7-azaindole in pure solvents increases with increasing temperature. Among them 5-Bromo-7-azaindole showed the best solubility in methyl acetate and the worst solubility in hexane. The maximum change in solubility of 5-Bromo-7-azaindole in DCM was observed at T = 298.15-313.15 K. The solubility of 5-Bromo-7-azaindole in DCM was found to be the most variable.

5-Bromo-7-azaindole synthesis

Synthesis of 5-Bromo-7-azaindole from 5-BROMO-1H-PYRROLO[2 , 3-B]PYRIDIN-2(3H)-ONE

5-Bromo-7-azaindole Preparation Products And Raw materials

Raw materials

ZINC 7-Azaindole tert-Butanol Boron trifluoride diethyl etherate Government regulation

Acetic acid Manganese triacetate dihydrate 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]- Acetamide, N-[5-bromo-3-[2-(trimethylsilyl)ethynyl]-2-pyridinyl]- 5-BROMO-1H-PYRROLO[2 , 3-B]PYRIDIN-2(3H)-ONE

3,3,5-Tribromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 2-Aminopyrrole 5-bromo-3-ethynylpyridin-2-amine Methyl 5-bromo-7-azaindole-3-carboxylate 5-BROMO-3-((TRIMETHYLSILYL)ETHYNYL)PYRIDIN-2-AMINE

5-BROMO-2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o

1of4

Preparation Products

1-PropanesulfonaMide, N-[3-[[5-broMo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]- 1H-PYRROLO[2,3-B]PYRIDIN-5-OL 5-Amino-7-azaindole

5-Bromo-7-azaindole Suppliers

Global( 607)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	431	58
Shanghai Jinli Pharmaceutical Co.,Ltd	+86-21-57256005 +86-15921811235	chang@shjlchem.com	China	20	58
Terma Medicare India Pvt.,Ltd	+8613916485955	shivshanghai@yahoo.com	India	150	58
Shanghai Yongzeng Technology Co.,Ltd	+86-021-65281118 +86-13818947575	sales@yongzchem.com	China	137	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20286	58
Watson Biotechnology Co.,Ltd	+86-18186686046 +86-18186686046	sales01@watsonbiotech.cn	China	5821	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55

Supplier	Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.	58
Shanghai Jinli Pharmaceutical Co.,Ltd	58
Terma Medicare India Pvt.,Ltd	58
Shanghai Yongzeng Technology Co.,Ltd	58
Hebei Weibang Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Watson Biotechnology Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from 5-Bromo-7-azaindole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-28	5-Bromo-7-azaindole 183208-35-7	US $0.00-0.00 / kg	1kg	99%	20MT	Watson Biotechnology Co.,Ltd
2024-11-28	5-Bromo-7-azaindole 183208-35-7	US $0.00 / KG	1KG	99%	20mt	Jinan Finer Chemical Co., Ltd
2024-11-22	5-Bromo-7-azaindole 183208-35-7	US $10.00 / KG	100KG	99%	100 mt	Hebei Weibang Biotechnology Co., Ltd

5-Bromo-7-azaindole
183208-35-7
US $0.00-0.00 / kg
99%
Watson Biotechnology Co.,Ltd

5-Bromo-7-azaindole
183208-35-7
US $0.00 / KG
99%
Jinan Finer Chemical Co., Ltd

5-Bromo-7-azaindole
183208-35-7
US $10.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

5-Bromo-7-azaindole Spectrum

5-Bromo-7-azaindole(183208-35-7)¹HNMR 5-Bromo-7-azaindole(183208-35-7)FT-IR

183208-35-7(5-Bromo-7-azaindole)Related Search:

Indole-3-butyric acid 1-(2,6-Dichlorophenyl)indolin-2-one 7-Azaindole N-Methyl-2-pyrrolidone Indometacin

N-Vinyl-2-pyrrolidone Pyrrolidine Polyvinylpyrrolidone Pyridine Indole-3-acetic acid

5-BROMO-1H-PYRROLO[2,3-C]PYRIDIN-2(3H)-ONE tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride No Chinese name rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl

5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE 1-METHYL-5-NITRO-1H-INDAZOLE 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester

1of4

5-BROMO-7-AZAINDOLE 5-Bromo-7-azaindole,96% 5-BROMO AZAINDOLE 1H-Pyrrolo[2,3-b]pyridine, 5-bromo- 5-Bromo-1H-pyrrolo2,3-büpyridine 5-Bromo-1H-pyrrolo[2,3-b]pyridine ,97% 5-Bromo-7-azaindole 97% 5-BroMo-7-azaindole, 97+% 5-Bromo-1H-pyrrolo[2,3-β]pyridine 5-Bromo-7-azaindole≥ 99% (HPLC) EOS-60661 5-Bromo-7-azaindole ISO 9001：2015 REACH SWF-57 SW-57 SKL277 5-BROMO-7-AZAINDOLE (5-BROMO-1H-PYRROLO(2,3-b) PYRIDINE Professional Supply API 5-Bromo-7-Azaindole CAS 183208-35-7 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE 3-Bromo-7H-pyrrolo[2,3-b]pyridine 5-bromo-7-azindole 5-BROMO-7-AZAINDOLE / 5-bromo-1H-pyrrolo[2,3-b]pyridine / Venetoclax Intermediate 183208-35-7 183208-35-9 183208-15-7 CHIRAL CHEMICALS pyridine Non-Chiral heterocyclic compounds Heterocycle-Indole series Heterocycle-Pyridine series Heterocycles Intermediate