5-Bromo-7-azaindole
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5-Bromo-7-azaindole 속성
- 녹는점
- 176-180 °C
- 끓는 점
- 357.4±42.0 °C(Predicted)
- 밀도
- 1.79±0.1 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,Room Temperature
- 산도 계수 (pKa)
- 6.25±0.20(Predicted)
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 노란색으로
- InChI
- InChI=1S/C7H5BrN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10)
- InChIKey
- LPTVWZSQAIDCEB-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=CC(Br)=CN=2
- LogP
- 1.8 at 25℃ and pH7
- CAS 데이터베이스
- 183208-35-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
5-Bromo-7-azaindole C화학적 특성, 용도, 생산
화학적 성질
White to light brown powder or crystalSynthesis
In the 250 ml flask is sequentially added in 50 ml ethanol and 5-bromo-1-hydrogen pyrrolo [2,3 - the b] pyridine -2 - ketone (4.2g, 20 mmol), Sn powder (4.7 g, 40 mmol) and 5 mol/L hydrochloric acid (14 ml), 40 ℃ stirring for 2 hours, the reaction is completed, to remove the ethanol, add 50 ml of water residue is completely dissolved, saturated NaHCO3 solution and to pH=8, and filtering the resulting solid, after drying, dissolved in 50 ml chloroform, adding CuBr2(13.4 g, 60mmol), 60 Cstirring for 2 hours, the reaction is completed, the end of the reaction, rotary evaporated to remove chloroform, adding 50 ml saturated NaHCO3 solution, ethyl acetate (3 × 100 ml), the combined organic phase with water (50 ml) for washing and then the saturated salt water (50 ml) washing, anhydrous Na2SO4 drying, filtering, the filtrate is concentrated to obtain 5-bromo-1H-pyrrolo [2,3 - the b] pyridine the crude product, the crude product is chloroform: hexane=2:1 (volume ratio) mixed solution recrystallize to get 3.1 g of pale yellow 5-Bromo-7-azaindole pure product, yield 77.6%, melting point:176.8-177.3 ℃.Solubility in organics
The solubility of 5-Bromo-7-azaindole in pure solvents increases with increasing temperature. Among them 5-Bromo-7-azaindole showed the best solubility in methyl acetate and the worst solubility in hexane. The maximum change in solubility of 5-Bromo-7-azaindole in DCM was observed at T = 298.15-313.15 K. The solubility of 5-Bromo-7-azaindole in DCM was found to be the most variable.5-Bromo-7-azaindole 준비 용품 및 원자재
원자재
아연
7-Azaindole
tert-부틸알코올
삼불화붕소화합물
브롬
아세트산(빙초산)
Manganese triacetate dihydrate
1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-
Acetamide, N-[5-bromo-3-[2-(trimethylsilyl)ethynyl]-2-pyridinyl]-
5-BROMO-1H-PYRROLO[2 , 3-B]PYRIDIN-2(3H)-ONE
3,3,5-Tribromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
2-아미노피롤
5-브로모-3-에티닐피리딘-2-아민
메틸5-브로모-7-아자인돌-3-카르복실레이트
5-브로모-3-((트리메틸실릴)에틸렌)피리딘-2-아민
5-BROMO-2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE
4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o
준비 용품
5-Bromo-7-azaindole 공급 업체
글로벌( 593)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Rochi Pharmaceutical Co.,Ltd. | 21-38751876 +8615000076078 |
info@rochipharma.com | China | 431 | 58 |
Shanghai Jinli Pharmaceutical Co.,Ltd | +86-21-57256005 +86-15921811235 |
chang@shjlchem.com | China | 20 | 58 |
Terma Medicare India Pvt.,Ltd | +8613916485955 |
shivshanghai@yahoo.com | India | 145 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20318 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21673 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9337 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
5-Bromo-7-azaindole 관련 검색:
3-인돌부틸산 인돌-3-아세트산 피리딘 폴리비닐피로리돈 피롤리딘 N-메틸-2-피롤리디논 인드메타신 2-피로리딘온,1-에테닐- 브롬
1-(2,6-Dichlorophenyl)indolin-2-one
7-Azaindole
5-BROMO-1H-PYRROLO[2,3-C]PYRIDIN-2(3H)-ONE
tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate
(6-Methylpyridazin-3-yl)MethanaMine dihydrochloride
No Chinese name
rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl
5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE
1-METHYL-5-NITRO-1H-INDAZOLE