Tomatidine hydrochloride
- CAS No.
- 6192-62-7
- Chemical Name:
- Tomatidine hydrochloride
- Synonyms
- TOMATIDINE HCL;TOMATIDINE HCL(RG);TOMATIDINE HYDROCHLORIDE;Tomatidine hydrochloride-RM;ToMatidin Hydrochloride, >85%;Tomatidine Hydrochloride, >5alpha-Tomatidan-3beta-ol HCl;Tomatidine, Hydrochloride, >85%;5α-Tomatidan-3β-ol hydrochloride;SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL
- CBNumber:
- CB6774105
- Molecular Formula:
- C27H46ClNO2
- Molecular Weight:
- 452.11
- MDL Number:
- MFCD11521518
- MOL File:
- 6192-62-7.mol
- MSDS File:
- SDS
| Melting point | 281-284°C (dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Methanol (Slightly) |
| form | Off-white solid |
| color | White to Off-White |
| BRN | 3920740 |
| FDA UNII | ENY5VJU5UB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Tomatidine hydrochloride price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T2909 | Tomatidine hydrochloride ≥85% | 6192-62-7 | 25mg | $75.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL80003 | Tomatidine hydrochloride phyproof? Reference Substance | 6192-62-7 | 20MG | $328 | 2023-01-07 | Buy |
| Sigma-Aldrich | 614350 | Tomatidine, HCl | 6192-62-7 | 25mg | $96.4 | 2023-01-07 | Buy |
| Cayman Chemical | 16938 | Tomatidine (hydrochloride) ≥90% | 6192-62-7 | 10mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 16938 | Tomatidine (hydrochloride) ≥90% | 6192-62-7 | 25mg | $66 | 2024-03-01 | Buy |
Tomatidine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid).
Biological Activity
Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.
Mode of action
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
Tomatidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29810 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3154 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
View Lastest Price from Tomatidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | TOMATIDINE HYDROCHLORIDE
6192-62-7
|
US $42.00 / mg | ≥95% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Tomatidine hydrochloride
6192-62-7
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
|
|
2023-02-24 | Tomatidine hydrochloride
6192-62-7
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- TOMATIDINE HYDROCHLORIDE
6192-62-7
- US $42.00 / mg
- ≥95%
- TargetMol Chemicals Inc.
-
- Tomatidine hydrochloride
6192-62-7
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Tomatidine hydrochloride
6192-62-7
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
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