SSR 69071
- CAS No.
- 344930-95-6
- Chemical Name:
- SSR 69071
- Synonyms
- SSR 69071;2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidin-4-one, 2-[[6-methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-
- CBNumber:
- CB6838847
- Molecular Formula:
- C27H32N4O7S
- Molecular Weight:
- 556.63
- MDL Number:
- MFCD09027353
- MOL File:
- 344930-95-6.mol
storage temp. | Store at +4°C |
---|---|
solubility | Soluble in DMSO |
form | solid |
color | Off-white |
FDA UNII | Z96REB2D8H |
SSR 69071 price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21477 | SSR 69071 ≥95% | 344930-95-6 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 21477 | SSR 69071 ≥95% | 344930-95-6 | 5mg | $122 | 2024-03-01 | Buy |
Cayman Chemical | 21477 | SSR 69071 ≥95% | 344930-95-6 | 10mg | $230 | 2024-03-01 | Buy |
Tocris | 2506 | SSR69071 ≥98%(HPLC) | 344930-95-6 | 10 | $242 | 2021-12-16 | Buy |
Usbiological | 256757 | SSR 69071 | 344930-95-6 | 10mg | $489 | 2021-12-16 | Buy |
SSR 69071 Chemical Properties,Uses,Production
Description
SSR 69071 is a potent inhibitor of neutrophil elastase (Ki = 0.0168 nM for the human enzyme). It is selective for human neutrophil elastase over rat, mouse, and rabbit elastases (Kis = 3, 1.8, 58 nM, respectively). It inhibits human neutrophil elastase ex vivo in mouse bronchoalveolar lavage (BAL) fluid (ED50 = 10.5 mg/kg, p.o.). In vivo, SSR 69071 (2.8 mg/kg, p.o.) reduces acute lung hemorrhage induced by human neutrophil elastase in mice. It reduces carrageenan- and human neutrophil elastase-induced paw edema in rats (ED30s = 2.2 and 2.7 mg/kg, respectively). SSR 69071 also reduces cardiac infarct size when administered prior to ischemia or reperfusion in a rabbit model of ischemia-reperfusion injury.
Uses
SSR 69071 is a novel and orally active elastase inhibitor.
Definition
ChEBI: 6-methoxy-1,1-dioxo-2-[[4-oxo-9-[2-(1-piperidinyl)ethoxy]-2-pyrido[1,2-a]pyrimidinyl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one is a pyridopyrimidine.
Biological Activity
Orally active, high affinity and potent inhibitor of human leukocyte elastase (HLE) (IC 50 = 3.9 nM). Displays species-selectivity (K i values are 0.017, 1.70, 3.01, 58 and > 100 nM? for human, mouse, rat, rabbit and porcine elastase respectively). In vivo, inhibits HLE-induced lung hemorrhage in mice (ID 50 = 2.8 mg/kg) and reduces infarct size in an acute model of coronary ischemia-reperfusion injury.
storage
Store at +4°C
SSR 69071 Preparation Products And Raw materials
Raw materials
Preparation Products
SSR 69071 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19690 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4578 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |