Sovilnesib
- CAS No.
- 2410796-79-9
- Chemical Name:
- Sovilnesib
- Synonyms
- AMG-650;AMG 650（Sovilnesib）;Sovilnesib;Sovilnesibum;Sovilnesib(AMG-650);Sovilnesib (Synonyms: AMG 650);Sovilnesib,AMG650,Inhibitor,inhibit,AMG 650,AMG-650,Microtubule/Tubulin;N-[2-(4,4-Difluoro-1-piperidyl)-6-methyl-4-pyrimidinyl]-4-(2-hydroxyethylsulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide;N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-4-((2-hydroxyethyl)sulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide;Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[(2-hydroxyethyl)sulfonyl]amino]-
- CBNumber:
- CB69768453
- Molecular Formula:
- C26H34F2N6O4S
- Molecular Weight:
- 564.65
- MDL Number:
- MOL File:
- 2410796-79-9.mol
| Density | 1.45±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| pka | 7.48±0.10(Predicted) |
| InChIKey | KBDGEJDIHZDPHN-UHFFFAOYSA-N |
| SMILES | C(NC1C=C(C)N=C(N2CCC(F)(F)CC2)N=1)(=O)C1=CC=C(NS(CCO)(=O)=O)C=C1N1CCC2(CC2)CC1 |
| FDA UNII | OP393M4H32 |
Sovilnesib Chemical Properties,Uses,Production
Description
Sovilnesib (AMG 650) is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer.
in vitro
Sovilnesib is a kinesin-like protein KIF18A inhibitor.
in vivo
Sovilnesib (AMG 650; 10-100 mg/kg; p.o. daily, for 45 d; female nude mice without thymus with OVCAR-3 xenografts) inhibits tumor growth, Lasting tumor regression and cure occurred in 50% of the animals, Sovilnesib has no apparent toxicity.
Clinical claims and research
Sovilnesib (AMG-650) is under development for the treatment of triple-negative breast cancer (TNBC), platinum-resistant high grade serous ovarian cancer, primary peritoneal cancer, fallopian tube cancer, serous endometrial cancer and other solid tumors with TP53 gene mutation (TP53MUT). The drug candidate is administered orally as tablet. It acts by targeting KIF18A.
Sovilnesib Preparation Products And Raw materials
Raw materials
Preparation Products
Sovilnesib Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Zhejiang Brunova Technology Co., Ltd. | 8617857108485 17857108485 | info@zjbrunova.com | China | 39 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | sales1@artkmedchem.com | China | 39009 | 58 |
| Zhejiang Brunova Technology Co., Ltd. | 13735468882 17857108485 | info@zjbrunova.com | China | 66 | 58 |
| Energy Chemical | 021-021-58432009 400-005-6266 | sales8178@energy-chemical.com | China | 44700 | 61 |
| NOTA Chemical (Shanghai) Co.,Ltd | 021-50189163 | sales@notachem.com | China | 199 | 64 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3427 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 |