Sovilnesib

2410796-79-9

CAS番号.: 2410796-79-9

化学名:

别名:

英語名:: Sovilnesib

英語别名:: AMG-650;AMG 650（Sovilnesib）;Sovilnesib;Sovilnesibum;Sovilnesib(AMG-650);Sovilnesib (Synonyms: AMG 650);Sovilnesib,AMG650,Inhibitor,inhibit,AMG 650,AMG-650,Microtubule/Tubulin;N-[2-(4,4-Difluoro-1-piperidyl)-6-methyl-4-pyrimidinyl]-4-(2-hydroxyethylsulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide;N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-4-((2-hydroxyethyl)sulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide;Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[(2-hydroxyethyl)sulfonyl]amino]-

CBNumber:: CB69768453

化学式:: C26H34F2N6O4S

分子量:: 564.65

MOL File:: 2410796-79-9.mol

物理性質

安全性情報

用途語

生産企業 37

Sovilnesib 物理性質

比重(密度) :: 1.45±0.1 g/cm3(Predicted)

貯蔵温度 :: Store at -20°C

酸解離定数(Pka):: 7.48±0.10(Predicted)

外見 :: Solid

色:: White to off-white

InChIKey:: KBDGEJDIHZDPHN-UHFFFAOYSA-N

SMILES:: C(NC1C=C(C)N=C(N2CCC(F)(F)CC2)N=1)(=O)C1=CC=C(NS(CCO)(=O)=O)C=C1N1CCC2(CC2)CC1

安全性情報

Sovilnesib 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

Sovilnesib 化学特性,用途語,生産方法

説明

Sovilnesib (AMG 650) is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer.

in vitro

Sovilnesib is a kinesin-like protein KIF18A inhibitor.

in vivo

Sovilnesib (AMG 650; 10-100 mg/kg; p.o. daily, for 45 d; female nude mice without thymus with OVCAR-3 xenografts) inhibits tumor growth, Lasting tumor regression and cure occurred in 50% of the animals, Sovilnesib has no apparent toxicity.

Sovilnesib 上流と下流の製品情報

原材料

準備製品

Sovilnesib 生産企業

Global( 37)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Zhejiang Brunova Technology Co., Ltd.	8617857108485 17857108485	info@zjbrunova.com	China	40	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Suzhou ARTK Medchem Co., Ltd.	+8618168183658	sales1@artkmedchem.com	China	39009	58
Zhejiang Brunova Technology Co., Ltd.	13735468882 17857108485	info@zjbrunova.com	China	67	58
Energy Chemical	021-021-58432009 400-005-6266	sales8178@energy-chemical.com	China	44700	61
NOTA Chemical (Shanghai) Co.,Ltd	021-50189163	sales@notachem.com	China	198	64
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3453	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4217	55

2410796-79-9
Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[(2-hydroxyethyl)sulfonyl]amino]-
Sovilnesib (Synonyms: AMG 650)
Sovilnesib
AMG 650（Sovilnesib）
AMG-650
Sovilnesib,AMG650,Inhibitor,inhibit,AMG 650,AMG-650,Microtubule/Tubulin
Sovilnesib(AMG-650)
N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-4-((2-hydroxyethyl)sulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide
N-[2-(4,4-Difluoro-1-piperidyl)-6-methyl-4-pyrimidinyl]-4-(2-hydroxyethylsulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide
Sovilnesibum