PAC1
- CAS No.
- 315183-21-2
- Chemical Name:
- PAC1
- Synonyms
- PAC1;DUSP2;PAC1-R;CS-243;PAC1（b）;ADCYAP1R1;PAC-1,PAC1;PAC-1 10MG;PAC 1, >=98%;Pac1 receptor
- CBNumber:
- CB71075505
- Molecular Formula:
- C23H28N4O2
- Molecular Weight:
- 392.49
- MDL Number:
- MFCD03302441
- MOL File:
- 315183-21-2.mol
| Density | 1.14 |
|---|---|
| storage temp. | Store at +4°C |
| solubility | DMSO: ≥10mg/mL |
| form | solid |
| pka | 8.82±0.40(Predicted) |
| color | white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months. |
| FDA UNII | 9LIS8N0B2C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335-H400 | |||||||||
| Precautionary statements | P261-P273-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-36/37/38-50/53 | |||||||||
| Safety Statements | 26-36/37-60-61 | |||||||||
| RIDADR | UN 3077 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
PAC1 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0115 | PAC-1 ≥98% (HPLC) | 315183-21-2 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | P0115 | PAC-1 ≥98% (HPLC) | 315183-21-2 | 25mg | $384 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAB1301755 | ANTI-DUSP2 (C-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 315183-21-2 | 400μL | $461 | 2023-01-07 | Buy |
| Cayman Chemical | 10009317 | PAC-1 ≥98% | 315183-21-2 | 25mg | $108 | 2024-03-01 | Buy |
| Cayman Chemical | 10009317 | PAC-1 ≥98% | 315183-21-2 | 50mg | $201 | 2024-03-01 | Buy |
PAC1 Chemical Properties,Uses,Production
Description
PAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2?? Sensitizes cancer cells to various chemotherapeutic agents.3
Uses
PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.
Biological Activity
Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively).
storage
+4°C
References
1) Putt et al. (2006), Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy; Nat. Chem. Biol., 2 543 2) Peterson et al. (2009), PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition; J. Mol. Biol., 388 144 3) Bolham et al. (2016), Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with diverse Chemotherapeutics; ACS Cent. Sci., 2 545
PAC1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22783 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
